A synthetic peptide for use as a blocking control in assays to test for specificity of CASP4 antibody, Alternative Names: CASP4 control peptide, CASP4 antibody Blocking Peptide, Anti-CASP4 Blocking Peptide, caspase 4, apoptosis-related cysteine peptidase Blocking Peptide, ICE(rel)II Blocking Peptide, ICEREL-II Blocking Peptide, ICH-2 Blocking Peptide, Mih1/TX Blocking Peptide, TX Blocking Peptide, CASP4, CASP-4, CASP 4, CASP-4 Blocking Peptide, CASP 4 Blocking Peptide
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.