This is a synthetic peptide designed for use in combination with anti-Bmi1 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Bmi1 is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.
Alias Symbols: AW546694, Bmi-1, Pcgf4
Protein Interaction Partner: Phc2,Rnf2,CBX4,CBX8,Cbx2,Dmap1,Dnmt3b,HSPA4,Kdm2b,PHC1,PHC2,PHC3,Phc1,Phc3,RING1,Rnf2,SCMH1,SMARCA5,Slc11a1