This is a synthetic peptide designed for use in combination with anti-CRSP6 antibody (Catalog #: ARP34192_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by CRSP6 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
Alias Symbols: CRSP6, CRSP77, DRIP80, TRAP80
Protein Interaction Partner: MED19,MED22,MED30,MED19,MED22,MED30,MED8,TP53,USP49,BARD1,BRCA1,BRD4,CDK8,ESR1,ESR2,GATA1,GPN1,HNF4A,MED1,MED10,MED18,MED19,MED25,MED26,MED28,MED29,MED30,MED9,PPARGC1A,RPAP2,SMARCA4,TP53