This is a synthetic peptide designed for use in combination with anti-CRYAB antibody (Catalog #: ARP48196_T100). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
Alpha crystallins are composed of: alpha-A and alpha-B, for acidic and basic, respectively. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases, a missense mutation cosegregated in a family with a desmin-related myopathy.
Alias Symbols: CRYA2, CTPP2, HSPB5
Protein Interaction Partner: BAX,BCL2L1,APP,BCL2L1,BMPR2,CRYAA,CRYAB,CRYBB2,CRYGC,CS,EPB41,HSPB1,PSMA3,TTN,BMPR2,CRYAA,CRYAB,CRYBB2,CRYGC,CS,HSPB1,HSPB2,PSMA3