This is a synthetic peptide designed for use in combination with anti-MLH1 antibody (Catalog #: ARP56076_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC.This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Alternatively spliced transcript variants encoding different isoforms have been described, but their full-length natures have not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: COCA2, FCC2, HNPCC, HNPCC2, MGC5172, hMLH1
Protein Interaction Partner: E2F1,E2F4,BLM,EXO1,EXO1,MBD4,MLH3,MSH4,MYC,PMS1,PMS2,AP2B1,BLM,BRCA1,CASP3,EXO1,FRMD6,MBD4,MLH3,MSH4,MYC,PMS1,PMS2,RAD9A,TRIM29,UBOX5,ZC3H11A,AIFM1,AMOT,AP2B1,ATAD3A,ATAD3B,ATM,ATP5A1,BLM,BRCA1,BRIP1,DOCK7,EXO1,EXO1,FRMD6,KPNA2,KPNB1,MBD4,MLH3,MRE11A,MSH2,MSH3,MSH4,MSH6,MTMR15,MYC,NBN,NTG2,PIK3C2A,PMS1,PMS2,PPP2R1A,PPP2R2A,PPP2R2B,PPP2R2D,PPP3CB,PPP3CC,PRKDC,PSD3,PYGB,RAD50,RFC1,RUVBL1,RUVBL2,SGS1,SMC1A,TRIM29,UBAP2L,UBC,UBOX5,WDR61,XRN1,YLPM1,ZC3H11A