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Ring Finger Protein 11-Like (RNF11L) (C-Term) Peptid

RNF11L Reaktivität: Human, Ratte Wirt: Synthetic BP, WB
Produktnummer ABIN983037
  • Target
    RNF11L (Ring Finger Protein 11-Like (RNF11L))
    Protein Region
    C-Term
    Spezies
    Human, Ratte
    Quelle
    Synthetic
    Applikation
    Blocking Peptide (BP), Western Blotting (WB)
    Sequenz
    GLIQHLPKGG YDPGRDGSEK KIRECVICMM DFVYGDPIRF LPCMHIYHLD
    Produktmerkmale
    This is a synthetic peptide designed for use in combination with anti-Rnf11l Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Aufreinigung
    Purified
  • Applikationshinweise
    Each Investigator should determine their own optimal working dilution for specific applications.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Konzentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    RNF11L (Ring Finger Protein 11-Like (RNF11L))
    Synonyme
    Rnf11 Peptide, ring finger protein 11-like 2 Peptide, Rnf11l2 Peptide
    Hintergrund
    Rnf11l is an essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Rnf11l promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Rnf11l recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

    Alias Symbols: Rnf11

    Protein Size: 280
    Molekulargewicht
    30 kDa
    Gen-ID
    316552
    NCBI Accession
    XM_237327, XP_237327
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