SOCS7
(Suppressor of Cytokine Signaling 7 (SOCS7))
Protein Region
N-Term
Spezies
Human
Quelle
Synthetic
Applikation
Blocking Peptide (BP), Western Blotting (WB)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-SOCS7 antibody (Catalog #: ARP53700_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
SOCS7 regulates signaling cascades probably through protein ubiquitination and/or sequestration. SOCS7 functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. SOCS7 inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. SOCS7 may be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Alias Symbols: NAP4, NCKAP4
Protein Interaction Partner: EGFR,GRB2,IRS2,IRS4,NCK1,PIK3R1,PIK3R2,PLCG1,SORBS3,TUBA1A,TUBB2C,NCK1