Blocking Peptide (BP), Western Blotting (WB), Immunohistochemistry (IHC)
Produktmerkmale
This is a synthetic peptide designed for use in combination with anti-TIMELESS antibody (Catalog #: ARP34186_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
The human Timeless protein interacts with both the circadian clock protein cryptochrome 2 and with the cell cycle checkpoint proteins Chk1 and the ATR-ATRIP complex and plays an important role in the DNA damage checkpoint response. Down-regulation of Timeless in human cells seriously compromises replication and intra-S checkpoints, indicating an intimate connection between the circadian cycle and the DNA damage checkpoints that is in part mediated by the Timeless protein.
Alias Symbols: TIM, TIM1, hTIM
Protein Interaction Partner: CRY1,PER1,PER2,TIPIN,ATRIP,CHEK1,CLSPN,CRY2,Clock,PCNA,Per1,Per2,TIPIN,per