PHGDH Produkte
(phosphoglycerate Dehydrogenase (PHGDH))
Kategorien
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011].
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Ausgewählte PHGDH Kategorien
PHGDH Antikörper
High quality antibodies with extensive validation data.
PHGDH ELISA Kits
Reliable ELISA kits for a wide range of species.
PHGDH Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PHGDH Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p), IF, IP
Validierungen
- (1)
- (10)
Kat. Nr.
ABIN565240
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p), IF, IP, IHC (fro), ICC
Validierungen
- (6)
Kat. Nr.
ABIN2855237
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IF, IP
Validierungen
- (5)
Kat. Nr.
ABIN6145554
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene PHGDH ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Competition ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969482
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Various Species
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN2815100
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6951683
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PHGDH Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1314910
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124414
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7479282
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PHGDH Produkten
: "Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 21, pp. 5392-5406, (2018) (PubMed).: "Systematic analysis of mRNA expression profiles in NSCLC cell lines to screen metastasis-related genes." in: Molecular medicine reports, Vol. 14, Issue 6, pp. 5093-5103, (2017) (PubMed).
: "PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis." in: Cancer research, Vol. 76, Issue 15, pp. 4430-42, (2016) (PubMed).
: "An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation." in: Cancer & metabolism, Vol. 3, pp. 5, (2015) (PubMed).
: "Cells deficient in base-excision repair reveal cancer hallmarks originating from adjustments to genetic instability." in: Nucleic acids research, Vol. 43, Issue 7, pp. 3667-79, (2015) (PubMed).
: "NRF2 regulates serine biosynthesis in non-small cell lung cancer." in: Nature genetics, Vol. 47, Issue 12, pp. 1475-81, (2015) (PubMed).
: "Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells." in: Nature, Vol. 493, Issue 7433, pp. 542-6, (2013) (PubMed).
: "Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis." in: PLoS genetics, Vol. 8, Issue 3, pp. e1002573, (2012) (PubMed).
: "Functional genomics reveal that the serine synthesis pathway is essential in breast cancer. ..." in: Nature, Vol. 476, Issue 7360, pp. 346-50, (2011) (PubMed).
: "Enhanced serine production by bone metastatic breast cancer cells stimulates osteoclastogenesis." in: Breast cancer research and treatment, Vol. 125, Issue 2, pp. 421-30, (2010) (PubMed).
Synonyme und alternative Namen zu PHGDH
phosphoglycerate dehydrogenase (phgdh), D-3-phosphoglycerate dehydrogenase (EDA9), D-3-phosphoglycerate dehydrogenase (serA), D-3-phosphoglycerate dehydrogenase (Sthe_2284), D-3-phosphoglycerate dehydrogenase (Dacet_1260), D-3-phosphoglycerate dehydrogenase (Mrub_0173), phosphoglycerate dehydrogenase (MMAH_RS07650), D-3-phosphoglycerate dehydrogenase (Arnit_0487), D-3-phosphoglycerate dehydrogenase (Ndas_0174), D-3-phosphoglycerate dehydrogenase (Mesil_2386), D-3-phosphoglycerate dehydrogenase (Slip_0010), D-3-phosphoglycerate dehydrogenase (Trad_0302), D-3-phosphoglycerate dehydrogenase (Acear_0027), D-3-phosphoglycerate dehydrogenase (Mahau_0665), phosphoglycerate dehydrogenase (MZHIL_RS05165), D-3-phosphoglycerate dehydrogenase (Mesop_1331), D-3-phosphoglycerate dehydrogenase (Thein_0855), 3-phosphoglycerate dehydrogenase (Phgdh), phosphoglycerate dehydrogenase (PHGDH), phosphoglycerate dehydrogenase (Phgdh), 3-PGDH, 3PGDH, 4930479N23, A10, ECK2909, embryo sac development arrest 9, F10M10.7, fb38f06, JW2880, PDG, PGAD, PGD, PGDH, SERA, wu:fb38f06, zgc:65956Bezeichner auf Proteinebene für PHGDH
- D-3-phosphoglycerate dehydrogenase
- 3-phosphoglycerate dehyrogenase
- 3-phosphoglycerate dehydrogenase
- 3-PGDH
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