PIP5K1A Produkte
(Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
Kategorien
Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.
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Ausgewählte PIP5K1A Kategorien
PIP5K1A Antikörper
High quality antibodies with extensive validation data.
PIP5K1A Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PIP5K1A Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF
Validierungen
- (4)
Kat. Nr.
ABIN948678
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7163185
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB
Validierungen
- (2)
- (2)
Kat. Nr.
ABIN392593
Menge
400 μL
Datenblatt
Datenblatt
Empfohlene PIP5K1A ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6220514
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PIP5K1A Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1315137
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1315135
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
Kat. Nr.
ABIN5509093
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PIP5K1A Produkten
: "Regulation of conformer-specific activation of the integrin LFA-1 by a chemokine-triggered Rho signaling module." in: Nature immunology, Vol. 10, Issue 2, pp. 185-94, (2009) (PubMed).: "Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice." in: Brain research. Molecular brain research, Vol. 134, Issue 2, pp. 239-55, (2005) (PubMed).
: "Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling." in: The Journal of biological chemistry, Vol. 278, Issue 25, pp. 23036-45, (2003) (PubMed).
: "Assignment of type I phosphatidylinositol-4-phosphate 5-kinase (PIP5K1A) to human chromosome bands 1q22--> q24 by in situ hybridization." in: Cytogenetics and cell genetics, Vol. 88, Issue 3-4, pp. 197-9, (2000) (PubMed).
Synonyme und alternative Namen zu PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (PIP5K1A), phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha (Pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog (pip5k1a.L), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha (pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha (Pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a (pip5k1aa), phosphatidylinositol-4-phosphate 5-kinase type 1 alpha (Pip5k1a), phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b (pip5k1ab), im:7140933, PIP5K1A, pip5k1a, Pip5k1b, pip5k1b, pip5k1c, Pipk5a, Pipk5b, zgc:110576, zgc:158838Bezeichner auf Proteinebene für PIP5K1A
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha
- PIP5K1-alpha
- PIP5KIalpha
- phosphatidylinositol 4-phosphate 5-kinase type I alpha
- phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
- phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
- ptdIns(4)P-5-kinase 1 alpha
- phosphatidylinositol-4-phosphate 5-kinase, type 1 beta
- phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
- phosphatidylinositol-4-phosphate 5-kinase, type I, beta
- 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase
- 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase
- PI4P5K-I[a]
- PI4P5KIbeta
- phosphatidylinositol 4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type I alpha
- phosphatidylinositol-4-phosphate 5-kinase type I beta
- phosphatidylinositol-4-phosphate 5-kinase type-1 gamma
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