PKD1 Produkte
(Polycystic Kidney Disease 1 (Autosomal Dominant) (PKD1))
Kategorien
This gene encodes a member of the polycystin protein family. The encoded glycoprotein contains a large N-terminal extracellular region, multiple transmembrane domains and a cytoplasmic C-tail. It is an integral membrane protein that functions as a regulator of calcium permeable cation channels and intracellular calcium homoeostasis. It is also involved in cell-cell/matrix interactions and may modulate G-protein-coupled signal-transduction pathways. It plays a role in renal tubular development, and mutations in this gene cause autosomal dominant polycystic kidney disease type 1 (ADPKD1). ADPKD1 is characterized by the growth of fluid-filled cysts that replace normal renal tissue and result in end-stage renal failure. Splice variants encoding different isoforms have been noted for this gene. Also, six pseudogenes, closely linked in a known duplicated region on chromosome 16p, have been described. [provided by RefSeq, Oct 2008].
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Ausgewählte PKD1 Kategorien
PKD1 Antikörper
High quality antibodies with extensive validation data.
PKD1 ELISA Kits
Reliable ELISA kits for a wide range of species.
PKD1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PKD1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC, IF
Validierungen
- (2)
Kat. Nr.
ABIN7163832
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
ELISA, WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro), ICC
Validierungen
- (4)
- (1)
Kat. Nr.
ABIN678083
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
ELISA, IHC, WB
Validierungen
- (1)
Kat. Nr.
ABIN3186481
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene PKD1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969448
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Competition ELISA
Validierungen
Kat. Nr.
ABIN6200495
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PKD1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7505263
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PKD1 Produkten
: "Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells." in: Human pathology, Vol. 65, pp. 231-238, (2017) (PubMed).: "Novel Transgenic Mouse Model of Polycystic Kidney Disease." in: The American journal of pathology, Vol. 187, Issue 9, pp. 1916-1922, (2017) (PubMed).
: "Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 31, pp. 11153-68, (2015) (PubMed).
: "Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors." in: Carcinogenesis, Vol. 34, Issue 6, pp. 1315-22, (2013) (PubMed).
Synonyme und alternative Namen zu PKD1
polycystin 1, transient receptor potential channel interacting (PKD1), polycystin 1, transient receptor poteintial channel interacting (Pkd1), polycystin 1, transient receptor potential channel interacting (Pkd1), polycystin-1 (LOC749291), mFLJ00285, PBP, Pc-1, PC1, TRPP1Bezeichner auf Proteinebene für PKD1
- autosomal dominant polycystic kidney disease 1 protein
- polycystic kidney disease-associated protein
- polycystin 1
- polycystin-1
- transient receptor potential cation channel, subfamily P, member 1
- autosomal dominant polycystic kidney disease 1 protein homolog
- polycystic kidney disease 1 homolog; polycystin-1
- polycystic kidney disease 1 (autosomal dominant)
- polycystic kidney disease protein 1
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