PLAU Produkte
(Plasminogen Activator, Urokinase (PLAU))
Kategorien
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009].
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Ausgewählte PLAU Kategorien
PLAU Antikörper
High quality antibodies with extensive validation data.
PLAU ELISA Kits
Reliable ELISA kits for a wide range of species.
PLAU Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PLAU Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, FACS, IHC (p)
Validierungen
- (8)
- (4)
Kat. Nr.
ABIN1882148
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IHC
Validierungen
- (5)
Kat. Nr.
ABIN185470
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, FACS, IF
Validierungen
- (6)
Kat. Nr.
ABIN3032244
Menge
0.4 mL
Datenblatt
Datenblatt
Empfohlene PLAU ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (8)
- (1)
Kat. Nr.
ABIN6958612
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6958613
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6976235
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PLAU Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (5)
Kat. Nr.
ABIN7275455
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Cynomolgus
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7275453
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (3)
Kat. Nr.
ABIN7275460
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PLAU Produkten
: "Aptamer-Based Sandwich Assay Formats for Detection and Discrimination of Human High- and Low-Molecular-Weight uPA for Cancer Prognosis and Diagnosis." in: Cancers, Vol. 14, Issue 21, (2022) (PubMed).: "Urokinase plasminogen activator secreted by cancer-associated fibroblasts induces tumor progression via PI3K/AKT and ERK signaling in esophageal squamous cell carcinoma." in: Oncotarget, Vol. 8, Issue 26, pp. 42300-42313, (2018) (PubMed).
: "Endothelial cell functions impaired by interferon in vitro: Insights into the molecular mechanism of thrombotic microangiopathy associated with interferon therapy." in: Thrombosis research, Vol. 163, pp. 105-116, (2018) (PubMed).
: "Effect of a synthetic inhibitor of urokinase plasminogen activator on the migration and invasion of human cervical cancer cells in vitro." in: Molecular medicine reports, Vol. 17, Issue 3, pp. 4273-4280, (2018) (PubMed).
: "Cytokine and estrogen stimulation of endothelial cells augments activation of the prekallikrein-high molecular weight kininogen complex: Implications for hereditary angioedema." in: The Journal of allergy and clinical immunology, Vol. 140, Issue 1, pp. 170-176, (2017) (PubMed).
: "Fucoxanthin Activates Apoptosis via Inhibition of PI3K/Akt/mTOR Pathway and Suppresses Invasion and Migration by Restriction of p38-MMP-2/9 Pathway in Human Glioblastoma Cells." in: Neurochemical research, Vol. 41, Issue 10, pp. 2728-2751, (2017) (PubMed).
: "Quantification of Circulating Cancer Biomarkers via Sensitive Topographic Measurements on Single Binder Nanoarrays." in: ACS omega, Vol. 2, Issue 6, pp. 2618-2629, (2017) (PubMed).
: "Methylation of neurofilament light polypeptide promoter is associated with cell invasion and metastasis in NSCLC." in: Biochemical and biophysical research communications, Vol. 470, Issue 3, pp. 627-34, (2016) (PubMed).
: "1,25-Dihydroxyvitamin D3 alleviates salivary adenoid cystic carcinoma progression by suppressing GPX1 expression through the NF-κB pathway." in: International journal of oncology, Vol. 48, Issue 3, pp. 1271-9, (2016) (PubMed).
: "miR-181a Induces Macrophage Polarized to M2 Phenotype and Promotes M2 Macrophage-mediated Tumor Cell Metastasis by Targeting KLF6 and C/EBPα." in: Molecular therapy. Nucleic acids, Vol. 5, Issue 9, pp. e368, (2016) (PubMed).
Synonyme und alternative Namen zu PLAU
plasminogen activator, urokinase (PLAU), urokinase-type plasminogen activator (CpipJ_CPIJ002131), urokinase-type plasminogen activator (CpipJ_CPIJ006543), urokinase-type plasminogen activator (CpipJ_CPIJ013396), urokinase-type plasminogen activator (CpipJ_CPIJ013623), plasminogen activator, urokinase (Plau), ATF, BDPLT5, PLAU, QPD, u-PA, UPA, uPA, UPAM, URKBezeichner auf Proteinebene für PLAU
- urokinase-type plasminogen activator
- U-plasminogen activator
- uPA
- plasminogen activator, urokinase
- plasminogen activator, urinary
- Urinary plasminogen activator, urokinase
- urokinase plasminogen activator preproprotein
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