PML Produkte
(Promyelocytic Leukemia (PML))
Kategorien
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions\; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
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Ausgewählte PML Kategorien
PML Antikörper
High quality antibodies with extensive validation data.
PML ELISA Kits
Reliable ELISA kits for a wide range of species.
PML Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PML Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IF, ELISA, PLA
Validierungen
- (6)
Kat. Nr.
ABIN562289
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC, IF, ELISA, ICC
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN6264315
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF, ELISA, FACS
Validierungen
- (6)
Kat. Nr.
ABIN3032330
Menge
0.4 mL
Datenblatt
Datenblatt
Empfohlene PML ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (4)
Kat. Nr.
ABIN6720583
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1381443
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6951212
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PML Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1315516
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
HEK-293 Cells
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN2729208
Menge
20 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7396061
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PML Produkten
: "PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment." in: Cell death and differentiation, pp. 1-13, (2022) (PubMed).: "Proteomic characterization of arsenic and cadmium exposure in bladder cells." in: Rapid communications in mass spectrometry : RCM, (2019) (PubMed).
: "Autophagy and Ubiquitin-Mediated Proteolytic Degradation of PML/Rarα Fusion Protein in Matrine-Induced Differentiation Sensitivity Recovery of ATRA-Resistant APL (NB4-LR1) Cells: in Vitro and in Vivo ..." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 48, Issue 6, pp. 2286-2301, (2018) (PubMed).
: "Evidence for Kaposi Sarcoma Originating from Mesenchymal Stem Cell through KSHV-induced Mesenchymal-to-Endothelial Transition." in: Cancer research, Vol. 78, Issue 1, pp. 230-245, (2018) (PubMed).
: "Visualization of PML nuclear import complexes reveals FG-repeat nucleoporins at cargo retrieval sites." in: Nucleus (Austin, Tex.), Vol. 8, Issue 4, pp. 404-420, (2018) (PubMed).
: "The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection." in: PLoS ONE, Vol. 12, Issue 1, pp. e0169648, (2017) (PubMed).
: "Sp100A is a tumor suppressor that activates p53-dependent transcription and counteracts E1A/E1B-55K-mediated transformation." in: Oncogene, Vol. 35, Issue 24, pp. 3178-89, (2016) (PubMed).
: "An Adenovirus DNA Replication Factor, but Not Incoming Genome Complexes, Targets PML Nuclear Bodies." in: Journal of virology, Vol. 90, Issue 3, pp. 1657-67, (2016) (PubMed).
: "The Arginine/Lysine-Rich Element within the DNA-Binding Domain Is Essential for Nuclear Localization and Function of the Intracellular Pathogen Resistance 1." in: PLoS ONE, Vol. 11, Issue 9, pp. e0162832, (2016) (PubMed).
: "PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53." in: Oncogene, Vol. 35, Issue 1, pp. 69-82, (2016) (PubMed).
Synonyme und alternative Namen zu PML
promyelocytic leukemia (PML), promyelocytic leukemia (Pml), 1200009E24Rik, AI661194, MYL, PML, PP8675, RGD1562602, RNF71, TRIM19, Trim19Bezeichner auf Proteinebene für PML
- RING finger protein 71
- probable transcription factor PML
- promyelocytic leukemia protein
- promyelocytic leukemia, inducer of
- protein PML
- tripartite motif protein TRIM19
- tripartite motif-containing protein 19
- promyelocytic leukemia
- probable transcription factor PML-like
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