POLG Produkte
(Polymerase (DNA Directed), gamma (POLG))
Kategorien
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte POLG Kategorien
POLG Antikörper
High quality antibodies with extensive validation data.
POLG ELISA Kits
Reliable ELISA kits for a wide range of species.
POLG Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene POLG Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC (p), IF, ICC, IP
Validierungen
- (5)
Kat. Nr.
ABIN2854742
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro)
Validierungen
- (1)
- (2)
Kat. Nr.
ABIN1714946
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p), ICC, IHC (fro)
Validierungen
- (2)
Kat. Nr.
ABIN7441298
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene POLG ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958688
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN5657981
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene POLG Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1315642
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7408237
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr.
ABIN3092149
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren POLG Produkten
: "The role of sodium hydrosulfide in attenuating the aging process via PI3K/AKT and CaMKKβ/AMPK pathways." in: Redox biology, Vol. 12, pp. 987-1003, (2017) (PubMed).: "DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria." in: DNA repair, Vol. 60, pp. 77-88, (2017) (PubMed).
: "Valproic acid-induced hepatotoxicity in Alpers syndrome is associated with mitochondrial permeability transition pore opening-dependent apoptotic sensitivity in an induced pluripotent stem cell model." in: Hepatology (Baltimore, Md.), Vol. 61, Issue 5, pp. 1730-9, (2015) (PubMed).
: "Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways. ..." in: BMC medical genomics, Vol. 6, pp. 22, (2013) (PubMed).
: "Subnormal levels of POLγA cause inefficient initiation of light-strand DNA synthesis and lead to mitochondrial DNA deletions and progressive external ophthalmoplegia [corrected]." in: Human molecular genetics, Vol. 22, Issue 12, pp. 2411-22, (2013) (PubMed).
: "Mitochondrial DNA base excision repair and mitochondrial DNA mutation in human hepatic HuH-7 cells exposed to stavudine." in: Mutation research, Vol. 664, Issue 1-2, pp. 28-38, (2009) (PubMed).
Synonyme und alternative Namen zu POLG
polymerase (DNA) gamma, catalytic subunit L homeolog (polg.L), DNA polymerase gamma, catalytic subunit (Polg), DNA polymerase gamma, catalytic subunit (POLG), polymerase (DNA directed), gamma (POLG), polymerase (DNA directed), gamma (polg), polymerase (DNA directed), gamma (Polg), AA409516, MDP1, MIRAS, MTDPS4A, MTDPS4B, PEO, POLG, POLG1, POLGA, PolgA, SANDO, SCAEBezeichner auf Proteinebene für POLG
- DNA polymerase gamma
- DNA polymerase subunit gamma-1
- DNA-directed DNA polymerase gamma
- mitochondrial DNA polymerase catalytic subunit
- polG-alpha
- polymerase (DNA directed), gamma
- DNA polymerase subunit gamma-1-like
- PolG-alpha
- DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha)
- Pol gamma
- mitochondrial DNA polymerase gamma
- mitochondrial DNA polymerase-gamma
- mitochondrial polymerase gamma
- polymerase, gamma
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