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POLH Produkte

(Polymerase (DNA Directed), eta (POLH))

Kategorien

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA\; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008].

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Ausgewählte POLH Kategorien

POLH Antikörper

High quality antibodies with extensive validation data.

POLH Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene POLH Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IHC, IF
Validierungen
  • (3)
Kat. Nr. ABIN7150247
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation WB, ELISA, IHC
Validierungen
  • (3)
Kat. Nr. ABIN7252888
Menge 200 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation WB, IF
Validierungen
  • (3)
Kat. Nr. ABIN7259837
Menge 200 μL
Datenblatt Datenblatt

Empfohlene POLH Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1315646
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3094678
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Mouse
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3137297
Menge 1 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren POLH Produkten

Barkley, Palle, Durando, Day, Gurkar, Kakusho, Li, Masai, Vaziri: "c-Jun N-terminal kinase-mediated Rad18 phosphorylation facilitates Polη recruitment to stalled replication forks." in: Molecular biology of the cell, Vol. 23, Issue 10, pp. 1943-54, (2012) (PubMed).

Day, Palle, Barkley, Kakusho, Zou, Tateishi, Verreault, Masai, Vaziri: "Phosphorylated Rad18 directs DNA polymerase η to sites of stalled replication." in: The Journal of cell biology, Vol. 191, Issue 5, pp. 953-66, (2010) (PubMed).

Parker, Bielen, Dikic, Ulrich: "Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase eta in Saccharomyces cerevisiae." in: Nucleic acids research, Vol. 35, Issue 3, pp. 881-9, (2007) (PubMed).

Skoneczna, McIntyre, Skoneczny, Policinska, Sledziewska-Gojska: "Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in Saccharomyces cerevisiae." in: Journal of molecular biology, Vol. 366, Issue 4, pp. 1074-86, (2007) (PubMed).

Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: "The DNA sequence and analysis of human chromosome 6. ..." in: Nature, Vol. 425, Issue 6960, pp. 805-11, (2003) (PubMed).

Glick, Vigna, Loeb: "Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions." in: The EMBO journal, Vol. 20, Issue 24, pp. 7303-12, (2001) (PubMed).

Yuasa, Masutani, Eki, Hanaoka: "Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene." in: Oncogene, Vol. 19, Issue 41, pp. 4721-8, (2000) (PubMed).

Masutani, Kusumoto, Yamada, Dohmae, Yokoi, Yuasa, Araki, Iwai, Takio, Hanaoka: "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta." in: Nature, Vol. 399, Issue 6737, pp. 700-4, (1999) (PubMed).

Johnson, Kondratick, Prakash, Prakash: "hRAD30 mutations in the variant form of xeroderma pigmentosum." in: Science (New York, N.Y.), Vol. 285, Issue 5425, pp. 263-5, (1999) (PubMed).

Synonyme und alternative Namen zu POLH

polymerase (DNA directed), eta S homeolog (polh.S), DNA polymerase eta (POLH), polymerase (DNA directed), eta (polh), DNA polymerase eta (Tb10.70.6190), putative DNA polymerase eta (LINJ_21_0690), polymerase (DNA directed), eta (Polh), DNA polymerase eta (LOC100443019), DNA polymerase eta (polh), DNA polymerase eta (Polh), polymerase (DNA directed), eta (RAD 30 related) (Polh), fc50a12, POLH, RAD30, RAD30A, wu:fc50a12, XP-V, XPV, zgc:136881, zgc:152642

Bezeichner auf Proteinebene für POLH

  • DNA-directed DNA polymerase eta
  • DNA polymerase eta
  • polymerase (DNA directed), eta
  • DNA polymerase eta-like
  • polymerase eta
  • RAD30 homolog A
  • xeroderma pigmentosum variant type protein
  • polymerase (DNA directed), eta (RAD 30 related)
  • xeroderma pigmentosum variant type protein homolog
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