PPP4C Produkte
(Protein Phosphatase 4, Catalytic Subunit (PPP4C))
Kategorien
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C- PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
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Ausgewählte PPP4C Kategorien
PPP4C Antikörper
High quality antibodies with extensive validation data.
PPP4C Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene PPP4C Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP
Validierungen
- (9)
Kat. Nr.
ABIN3022939
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC, IF
Validierungen
- (5)
Kat. Nr.
ABIN7260177
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
- (3)
Kat. Nr.
ABIN669261
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene PPP4C ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969743
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene PPP4C Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1316083
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1316081
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2131274
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren PPP4C Produkten
: "Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers." in: eLife, Vol. 3, pp. e01695, (2014) (PubMed).: "Protein phosphatase 4 regulates apoptosis, proliferation and mutation rate of human cells." in: Biochimica et biophysica acta, Vol. 1783, Issue 8, pp. 1490-502, (2008) (PubMed).
: "Suppression of MEK/ERK signaling pathway enhances cisplatin-induced NF-kappaB activation by protein phosphatase 4-mediated NF-kappaB p65 Thr dephosphorylation." in: The Journal of biological chemistry, Vol. 279, Issue 25, pp. 26143-8, (2004) (PubMed).
: "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation." in: The Journal of biological chemistry, Vol. 279, Issue 45, pp. 46588-94, (2004) (PubMed).
: "Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1." in: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49551-61, (2004) (PubMed).
Synonyme und alternative Namen zu PPP4C
protein phosphatase 4 catalytic subunit (ppp4c), protein phosphatase 4, catalytic subunit a (ppp4ca), protein phosphatase 4 catalytic subunit (PPP4C), protein phosphatase 4, catalytic subunit (Ppp4c), protein phosphatase 4 catalytic subunit S homeolog (ppp4c.S), 1110002D08Rik, AU016079, gc:56413, MGC75928, pp4, PP4, pp4c, PP4C, PP4C-A, pph3, PPH3, PPP4, ppp4c, ppx, PPX, Ppx, wu:fd05e08, zgc:56413Bezeichner auf Proteinebene für PPP4C
- protein phosphatase 4, catalytic subunit
- catalytic subunit
- serine/threonine-protein phosphatase 4 catalytic subunit A
- PP-X
- protein phosphatase 4 (formerly X), catalytic subunit
- protein phosphatase X, catalytic subunit
- serine/threonine-protein phosphatase 4 catalytic subunit
- PP4C
- pp4
- protein phosphatase X
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