Presenilin 1 Produkte
(Presenilin 1 (PSEN1))
Kategorien
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1\; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008].
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Ausgewählte Presenilin 1 Kategorien
Presenilin 1 Antikörper
High quality antibodies with extensive validation data.
Presenilin 1 ELISA Kits
Reliable ELISA kits for a wide range of species.
Presenilin 1 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Presenilin 1 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (6)
Kat. Nr.
ABIN3023160
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IHC (p), FACS, IF
Validierungen
- (1)
- (4)
Kat. Nr.
ABIN390169
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7164264
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene Presenilin 1 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6958721
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969495
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958722
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Presenilin 1 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1316518
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7414045
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7412977
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Presenilin 1 Produkten
: "Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy." in: Disease models & mechanisms, Vol. 12, Issue 12, (2020) (PubMed).: "Vitamin D receptor is present on the neuronal plasma membrane and is co-localized with amyloid precursor protein, ADAM10 or Nicastrin." in: PLoS ONE, Vol. 12, Issue 11, pp. e0188605, (2017) (PubMed).
: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).
: "Nonsteroidal Anti-inflammatory Drugs: Do They Increase the Risk of Anastomotic Leaks Following Colorectal Operations?" in: Diseases of the colon and rectum, Vol. 58, Issue 9, pp. 870-7, (2015) (PubMed).
: "Biomarkers of Alzheimer disease, insulin resistance, and obesity in childhood." in: Pediatrics, Vol. 135, Issue 6, pp. 1074-81, (2015) (PubMed).
: "Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 32, Issue 31, pp. 10674-85, (2012) (PubMed).
: "Low molecular weight, non-peptidic agonists of TrkA receptor with NGF-mimetic activity." in: Cell death & disease, Vol. 3, pp. e389, (2012) (PubMed).
: "Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 41, pp. 16558-63, (2012) (PubMed).
: "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-?4?2 nAChR-APP695 cells." in: Neurochemical research, Vol. 36, Issue 5, pp. 904-12, (2011) (PubMed).
: "Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca2+ levels and dynamics." in: Molecular bioSystems, Vol. 6, Issue 9, pp. 1640-9, (2010) (PubMed).
Synonyme und alternative Namen zu Presenilin 1
presenilin 1 (psen1), presenilin 1 (PSEN1), presenilin 1 (Psen1), presenilin 1 L homeolog (psen1.L), ad3, AD3, Ad3h, fad, FAD, pre1, PS-1, ps1, PS1, psen, s182, S182, X-PS-alpha, X-PS-beta, zf-PS1, zfPS1Bezeichner auf Proteinebene für Presenilin 1
- PS-1
- presenilin-1
- presenilin 1 (Alzheimer disease 3)
- presenilin-1 isoform I-463
- presenilin-1 isoform I-467
- presenilin 1
- presenilin-1-like
- PS-alpha
- presenilin alpha
- presenilin-alpha
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