Presenilin 2 Produkte
(Presenilin 2 (Alzheimer Disease 4) (PSEN2))
Kategorien
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008].
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Ausgewählte Presenilin 2 Kategorien
Presenilin 2 Antikörper
High quality antibodies with extensive validation data.
Presenilin 2 ELISA Kits
Reliable ELISA kits for a wide range of species.
Presenilin 2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Presenilin 2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IHC (p), IHC (fro)
Validierungen
- (6)
Kat. Nr.
ABIN3032302
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, FACS
Validierungen
- (4)
- (2)
Kat. Nr.
ABIN1944732
Menge
400 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
IHC, IF
Validierungen
- (3)
Kat. Nr.
ABIN7263725
Menge
200 μL
Datenblatt
Datenblatt
Empfohlene Presenilin 2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6969496
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958724
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rabbit
Analytical Method
Quantitative
Validierungen
- (1)
Kat. Nr.
ABIN775490
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Presenilin 2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1316520
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Rat
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7411894
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human, Monkey, Rat
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN2751153
Menge
5 applications
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Presenilin 2 Produkten
: "Novel MITF targets identified using a two-step DNA microarray strategy." in: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, (2008) (PubMed).: "(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates." in: Pediatric research, Vol. 61, Issue 6, pp. 727-31, (2007) (PubMed).
: "A novel mutation in the PSEN2 gene (T430M) associated with variable expression in a family with early-onset Alzheimer disease." in: Archives of neurology, Vol. 60, Issue 8, pp. 1149-51, (2003) (PubMed).
: "Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population." in: Neuroscience letters, Vol. 343, Issue 3, pp. 210-2, (2003) (PubMed).
: "In vitro characterization of the presenilin-dependent gamma-secretase complex using a novel affinity ligand." in: Biochemistry, Vol. 42, Issue 27, pp. 8133-42, (2003) (PubMed).
: "Increased expression of presenilin 2 inhibits protein synthesis." in: Molecular and cellular neurosciences, Vol. 19, Issue 1, pp. 111-24, (2002) (PubMed).
: "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein." in: The Journal of biological chemistry, Vol. 277, Issue 15, pp. 12915-20, (2002) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
: "High prevalence of pathogenic mutations in patients with early-onset dementia detected by sequence analyses of four different genes." in: American journal of human genetics, Vol. 66, Issue 1, pp. 110-7, (2000) (PubMed).
: "Genomic structure and expression of STM2, the chromosome 1 familial Alzheimer disease gene." in: Genomics, Vol. 34, Issue 2, pp. 198-204, (1997) (PubMed).
Synonyme und alternative Namen zu Presenilin 2
presenilin 2 (PSEN2), presenilin 2 (Psen2), presenilin 2 (psen2), presenilin 2 S homeolog (psen2.S), presenilin 2 (Alzheimer disease 4) (PSEN2), trefoil factor 1 (Tff1), AD3L, ad3l, AD4, ad4, Ad4h, ALG-3, Alg3, CMD1V, pre2, PS-2, PS2, ps2, Ps2, PSEN2, Psnl2, PSNL2, STM2, stm2, zf-PS2Bezeichner auf Proteinebene für Presenilin 2
- AD3LP
- AD5
- E5-1
- PS-2
- STM-2
- presenilin-2
- PS-beta
- presenilin beta
- presenilin-beta
- presenilin 2 (Alzheimer disease 4)
- protein pS2
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