Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Produkte
(Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A (PPM1A))
Kategorien
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
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Ausgewählte Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Kategorien
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Antikörper
High quality antibodies with extensive validation data.
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A ELISA Kits
Reliable ELISA kits for a wide range of species.
Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IP, ICC
Validierungen
- (6)
Kat. Nr.
ABIN7441469
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, FACS
Validierungen
- (2)
- (5)
Kat. Nr.
ABIN969556
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IF, IHC (p), PLA
Validierungen
- (5)
Kat. Nr.
ABIN519084
Menge
100 μg
Datenblatt
Datenblatt
Empfohlene Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6958947
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6958948
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN6730765
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1315905
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7320335
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7505335
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Produkten
: "Protein phosphatase magnesium-dependent 1A induces inflammation in rheumatoid arthritis." in: Biochemical and biophysical research communications, Vol. 522, Issue 3, pp. 731-735, (2020) (PubMed).: "The intracellular protein phosphatase magnesium-dependent 1A negatively regulates osteoclast commitment." in: Arthritis & rheumatology (Hoboken, N.J.), (2019) (PubMed).
: "NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction." in: The Journal of biological chemistry, Vol. 292, Issue 19, pp. 7866-7887, (2017) (PubMed).
: "Role of protein phosphatase magnesium-dependent 1A and anti-protein phosphatase magnesium-dependent 1A autoantibodies in ankylosing spondylitis." in: Arthritis & rheumatology (Hoboken, N.J.), Vol. 66, Issue 10, pp. 2793-803, (2014) (PubMed).
: "Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants." in: Biological psychiatry, Vol. 69, Issue 4, pp. 360-5, (2011) (PubMed).
: "PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation." in: Cellular signalling, Vol. 21, Issue 1, pp. 95-102, (2008) (PubMed).
: "PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling." in: Cell, Vol. 125, Issue 5, pp. 915-28, (2006) (PubMed).
: "Protein serine/threonine phosphatase PPM1A dephosphorylates Smad1 in the bone morphogenetic protein signaling pathway." in: The Journal of biological chemistry, Vol. 281, Issue 48, pp. 36526-32, (2006) (PubMed).
: "Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes." in: The Journal of biological chemistry, Vol. 279, Issue 21, pp. 22715-26, (2004) (PubMed).
: "Cell cycle regulation and p53 activation by protein phosphatase 2C alpha." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 14299-305, (2003) (PubMed).
Synonyme und alternative Namen zu Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A
protein phosphatase, Mg2+/Mn2+ dependent 1A (PPM1A), protein phosphatase, Mg2+/Mn2+ dependent, 1Ab (ppm1ab), protein phosphatase 1A, magnesium dependent, alpha isoform (Ppm1a), protein phosphatase, Mg2+/Mn2+ dependent, 1A (Ppm1a), protein phosphatase, Mg2+/Mn2+ dependent 1A L homeolog (ppm1a.L), protein phosphatase, Mg2+/Mn2+ dependent 1A (Ppm1a), protein phosphatase, Mg2+/Mn2+ dependent, 1Aa (ppm1aa), 2310003C21Rik, 2900017D14Rik, AI427932, AU017636, MMPa-2, MPPa-1, PP2C-ALPHA, pp2c-alpha, Pp2c1, PP2CA, pp2ca, pp2ca1, pp2ca2, PP2Calpha, pp2calpha, ppp1r13b, si:ch211-253p18.1, wu:fd42g12, zgc:153820Bezeichner auf Proteinebene für Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A
- protein phosphatase 1A
- protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
- protein phosphatase type 2C alpha 1
- protein phosphatase 1, regulatory (inhibitor) subunit 13B
- Mpp alpha
- PP2C-alpha
- protein phosphatase 2C isoform alpha
- protein phosphatase IA
- IA
- Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform
- Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform
- protein phosphatase 1A, magnesium dependent, alpha isoform
- protein phosphatase 2C alpha
- protein phosphatase type 2C alpha 2
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