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IL-33 Protein (AA 109-266)

IL33 Spezies: Human, Maus Wirt: Escherichia coli (E. coli) Recombinant >95 % (SDS-PAGE) SDS Active
Produktnummer ABIN1343980
  • Target Alle IL-33 (IL33) Proteine anzeigen
    IL-33 (IL33) (Interleukin 33 (IL33))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 109-266
    Spezies
    • 17
    • 13
    • 4
    • 2
    • 1
    • 1
    • 1
    Human, Maus
    Quelle
    • 24
    • 8
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Applikation
    SDS-PAGE (SDS)
    Spezifität
    Binds to mouse and human ST2.
    Kreuzreaktivität
    Human, Maus
    Produktmerkmale
    Mouse IL-33 (aa 109-266) is untagged.
    Reinheit
    >95 % (SDS-PAGE)
    Endotoxin-Niveau
    <0.1EU/μg purified protein (LAL test, Lonza).
    Top Product
    Discover our top product IL33 Protein
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Kommentare

    Activates ST2-dependent NF-kappaB pathway.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstitute with 100 μL sterile water.
    Konzentration
    Lot specific
    Buffer
    Lyophilized. Contains PBS.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 6 months after receipt when stored at -20°C.
    Haltbarkeit
    6 months
  • Target
    IL-33 (IL33) (Interleukin 33 (IL33))
    Andere Bezeichnung
    IL-33 (IL33 Produkte)
    Synonyme
    IL33 Protein, C9orf26 Protein, DVS27 Protein, IL1F11 Protein, NF-HEV Protein, NFEHEV Protein, RP11-575C20.2 Protein, 9230117N10Rik Protein, Il-33 Protein, Il1f11 Protein, RGD1311155 Protein, interleukin 33 Protein, IL33 Protein, Il33 Protein
    Hintergrund
    Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
    Molekulargewicht
    ~18kDa
    UniProt
    Q2YEJ4
    Pathways
    Production of Molecular Mediator of Immune Response
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