FIL1h Protein (AA 31-183)

Produktnummer ABIN1344000

Produktdetails

Target: FIL1h (Interleukin 1 eta (FIL1h))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 31-183

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS)

Kreuzreaktivität: Maus

Produktmerkmale: Mouse IL-36beta (aa Ser31-Lys183) is untagged.

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.01EU/μg purified protein (LAL test, Lonza).

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Induces secretion of IL-6 in BMDCs at a concentration of 10 - 100ng/ml.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with 100 μL sterile water.

Konzentration: Lot specific

Buffer: Lyophilized. Contains PBS + 0.5 % Trehalose.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: FIL1h (Interleukin 1 eta (FIL1h))

Andere Bezeichnung: IL-36 beta (FIL1h Produkte)

Synonyme: 2310043N20Rik Protein, Il36b Protein, FIL1 Protein, FIL1-(ETA) Protein, FIL1H Protein, FILI-(ETA) Protein, IL-1F8 Protein, IL-1H2 Protein, IL1-ETA Protein, IL1F8 Protein, IL1H2 Protein, Il1f8 Protein, interleukin 1 family, member 8 Protein, interleukin 36 beta Protein, interleukin 36, beta Protein, Il1f8 Protein, IL36B Protein, Il36b Protein

Hintergrund: IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1 and are inhibited by IL-36Ra. The expression of IL-36 cytokines has been shown to occur at different sites including the lung and skin and can be derived from diverse cell types including keratinocytes, bronchial epithelium as well as macrophages, monocytes and different T cell subsets. IL-36 family members induce the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.

Molekulargewicht: ~17kDa

UniProt: Q9D6Z6