TNFRSF10A Protein (AA 24-239, Extracellular Domain) (Fc Tag)
-
- Target Alle TNFRSF10A Proteine anzeigen
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- Extracellular Domain, AA 24-239
- Spezies
- Human, Maus
-
Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses TNFRSF10A Protein ist gelabelt mit Fc Tag.
- Applikation
- SDS-PAGE (SDS)
- Spezifität
- Binds to human and mouse TRAIL.
- Kreuzreaktivität
- Human, Maus
- Produktmerkmale
- The extracellular domain of human TRAIL-R1 (aa 24-239) is fused to the Fc portion of human IgG1.
- Reinheit
- >95 % (SDS-PAGE)
- Endotoxin-Niveau
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFRSF10A Protein
-
-
- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
-
Blocks human or mouse TRAIL activity in a concentration of 1-10μg/ml.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Rekonstitution
- Reconstitute with 50 μL sterile water.
- Konzentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
-
Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Haltbarkeit
- 6 months
-
- Target
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
- Andere Bezeichnung
- TRAIL-R1 (TNFRSF10A Produkte)
- Synonyme
- APO2 Protein, CD261 Protein, DR4 Protein, TRAILR-1 Protein, TRAILR1 Protein, TNFRSF10A Protein, TNF receptor superfamily member 10a Protein, tumor necrosis factor receptor superfamily member 26 Protein, tumor necrosis factor receptor superfamily, member 10a Protein, TNFRSF10A Protein, LOC510798 Protein
- Hintergrund
- TRAIL-R1 (DR4, CD261) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
- Molekulargewicht
- ~52kDa (SDS-PAGE)
- UniProt
- O00220
- Pathways
- Apoptose, Positive Regulation of Endopeptidase Activity
-