TNFSF18 Protein (AA 45-173, Extracellular Domain, Soluble) (DYKDDDDK Tag)
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- Target Alle TNFSF18 Proteine anzeigen
- TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- Soluble, Extracellular Domain, AA 45-173
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Spezies
- Maus
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Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses TNFSF18 Protein ist gelabelt mit DYKDDDDK Tag.
- Applikation
- SDS-PAGE (SDS)
- Spezifität
- Binds to mouse GITR.
- Kreuzreaktivität
- Maus
- Produktmerkmale
- The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG®-tag.
- Reinheit
- >90 % (SDS-PAGE)
- Sterilität
- 0.2 μm filtered
- Endotoxin-Niveau
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFSF18 Protein
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Kommentare
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Induces GITR-mediated NF-kappaB activation in HEK 293 cells.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- 0.2μm-filtered solution in 10 mM glycine, pH 10.0.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
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Short Term Storage: +4°C
Long Term Storage: -20°C
Working aliquots are stable for up to 3 months when stored at -20°C. - Haltbarkeit
- 3 months
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- Target
- TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))
- Andere Bezeichnung
- GITRL (TNFSF18 Produkte)
- Synonyme
- Gitrl Protein, AITRL Protein, GITRL Protein, TL6 Protein, hGITRL Protein, TNLG2A Protein, tumor necrosis factor (ligand) superfamily, member 18 Protein, TNF superfamily member 18 Protein, Tnfsf18 Protein, TNFSF18 Protein
- Hintergrund
- GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.
- Molekulargewicht
- ~22kDa (SDS-PAGE)
- UniProt
- Q7TS55
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