Annexin V Protein (GST tag)

Produktnummer ABIN1344454

Produktdetails

Target: Annexin V (ANXA5) (Annexin A5 (ANXA5))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Aufreinigungstag / Konjugat: Dieses Annexin V Protein ist gelabelt mit GST tag.

Applikation: SDS-PAGE (SDS)

Spezifität: Binds to phosphatidylserine (PS).

Kreuzreaktivität: Human

Produktmerkmale: Recombinant human annexin V fused to a GST-tag.

Reinheit: >95 % (SDS-PAGE)

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute with 100 μL sterile water.

Konzentration: Lot specific

Buffer: Lyophilized. In PBS, pH 7.4.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. Reconstituted solutions can be kept at 4°C under sterile conditions for one week or should be frozen in aliquots at -20°C.

Haltbarkeit: 12 months

Referenzen

Morizono, Chen: "Role of phosphatidylserine receptors in enveloped virus infection." in: Journal of virology, Vol. 88, Issue 8, pp. 4275-90, (2014) (PubMed).

Antigendetails

Target: Annexin V (ANXA5) (Annexin A5 (ANXA5))

Andere Bezeichnung: Annexin V (ANXA5 Produkte)

Hintergrund: Annexin V is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Annexin V competes for phosphatidylserine binding sites (e.g. platelets) with prothrombin or coagulation factors and inhibis the activity of phospholipase A1. Antibodies directed against annexin V are found in patients with a disease called the antiphospholipid syndrome(APS), a thrombophilic disease associated with autoantibodies against phospholipid compounds. Annexin V is used as a probe in the "annexin V affinity assay" to detect cells that have expressed phosphatidylserine on the cell surface, a feature found in apoptosis and other forms of cell death.

Molekulargewicht: ~52kDa (SDS-PAGE)

UniProt: P08758

Pathways: Apoptose