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VEGFA Protein (Homodimer)

VEGFA Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE Active
Produktnummer ABIN1589530
  • Target Alle VEGFA Proteine anzeigen
    VEGFA (Vascular Endothelial Growth Factor A (VEGFA))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    Homodimer
    Spezies
    • 17
    • 14
    • 12
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Quelle
    • 34
    • 14
    • 13
    • 4
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Verwendungszweck
    VEGF120
    Sequenz
    APTTEGEQKA HEVVKFMDVY QRSYCRPIET LVDIFQEYPD EIEYIFKPSC VPLMRCAGCC NDEALECVPT SESNVTMQIM RIKPHQSQHI GEMSFLQHSR CECRPKKDRT KPEKCDKPRR
    Produktmerkmale
    Length (aa):120
    Reinheit
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product VEGFA Protein
  • Applikationshinweise
    Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) using a concentration range of 2-10 ng/mL.
    Kommentare

    Cytokines & Growth Factors

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    The lyophilized VEGF120 should be reconstituted in ddH2O to a concentration not lower than 50 μg/mL.
    Buffer
    PBS
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Lyophilized samples are stable for greater than six months at -20°C to -70°C. Reconstituted VEGF120 should be stored in working aliquots at -20°C.
    Haltbarkeit
    6 months
  • Target
    VEGFA (Vascular Endothelial Growth Factor A (VEGFA))
    Andere Bezeichnung
    VEGF120 (VEGFA Produkte)
    Synonyme
    MVCD1 Protein, VEGF Protein, VPF Protein, Vegf Protein, Vegf120 Protein, Vegf164 Protein, Vegf188 Protein, Vpf Protein, vegf Protein, vegfa Protein, wu:fj82c06 Protein, VEGF-A Protein, VEGF164 Protein, eVEGF120 Protein, eVEGF164 Protein, vegf-a Protein, vpf Protein, vefg Protein, si:dkey-14d8.3 Protein, wu:fd42e02 Protein, vascular endothelial growth factor A Protein, vascular endothelial growth factor Aa Protein, vascular endothelial growth factor A L homeolog Protein, vascular endothelial growth factor Ab Protein, VEGFA Protein, Vegfa Protein, vegfaa Protein, vegfa.L Protein, vegfa Protein, vegfab Protein
    Hintergrund
    Rat Vascular Endothelial Growth Factor120 (VEGF120), a 14.1 kDa protein consisting of 120 amino acid residues, is produced as a homodimer. VEGF120 is a polypeptide growth factor and a member of the platelet-derived growth factor family. It is a specific mitogen for vascular endothelial cells and a strong angiogenic factor in vivo. Two high-affinity tyrosine kinase receptors for VEGF120 have been identified, VEGFR-1 (FLT-1), and VEGFR-2 (Flk-1). Consistent with the endothelial cell-specific action of VEGF120, expression of both receptor genes has been found predominantly but not exclusively on endothelial cells. Expression of VEGFR-1 was also found on human monocytes, neutrophils (PMNs), bovine brain pericytes and villous and extravillous trophoblasts. In addition to its action as a mitogen it is a potent vascular permeability factor (VPF) in vivo and is also a chemo attractant for monocytes and endothelial cells. At least four different proteins are generated by differential splicing of the mouse VEGF gene: VEGF120, VEGF144, VEGF164 and VEGF188. The most abundant form is VEGF164. Whereas VEGF120, VEGF144 and VEGF164 are secreted proteins, VEGF188 is strongly cell-associated. In addition, the isoforms VEGF164 and VEGF188 bind to heparin with high affinity. All dimeric forms possess similar biological activities. A related protein of VEGF is placenta growth factor (PlGF) with about 53% homology and VEGF-B with similar biological activities. The full ORF of native rat VEGF120 (Ala27-Arg146) was cloned from total RNA of rat sinusoidal endothelial cells using standard protocols.
    Synonyms: Vascular Endothelial Growth Factor A, Vegfa, Vegf, VEGF120
    Molekulargewicht
    14.02 kDa
    Gen-ID
    83785
    NCBI Accession
    NM_031836
    UniProt
    P16612
    Pathways
    RTK Signalweg, Glycosaminoglycan Metabolic Process, Regulation of Cell Size, Tube Formation, Signaling Events mediated by VEGFR1 and VEGFR2, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling
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