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Podoplanin Protein (PDPN) (Soluble) (His tag)

PDPN Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE
Produktnummer ABIN1589760
  • Target Alle Podoplanin (PDPN) Proteine anzeigen
    Podoplanin (PDPN)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    Soluble
    Spezies
    • 11
    • 9
    • 4
    • 2
    • 1
    • 1
    Human
    Quelle
    • 11
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Aufreinigungstag / Konjugat
    Dieses Podoplanin Protein ist gelabelt mit His tag.
    Verwendungszweck
    Podoplanin, soluble
    Sequenz
    GSSHHHHHHS SGLVPRGSHM EGASTGQPED DTETTGLEGV AMPGAEDDVV TPGTSEDRYK SGLTTLVATS VNSVTGIRIE DLPTSESTVH AQEQSPSATA SNVATSHsTE KVDGDTQTTV EKDGLST
    Spezifität
    Chromosomal location:1p36.21
    Produktmerkmale
    Length (aa):127
    Reinheit
    > 95 % by SDS-PAGE
    Top Product
    Discover our top product PDPN Protein
  • Kommentare

    Soluble Receptors

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    We recommend a quick spin followed by reconstitution in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers and stored at 4 °C for 1 week or -20 °C for future use.
    Buffer
    PBS
    Handhabung
    Centrifuge vial prior to opening.
    Lagerung
    RT,-20 °C
    Informationen zur Lagerung
    The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20°C. Reconstituted sPodoplanin should be stored in working aliquots at -20°C.
  • Target
    Podoplanin (PDPN)
    Andere Bezeichnung
    Podoplanin (PDPN Produkte)
    Synonyme
    PDPN Protein, AGGRUS Protein, GP36 Protein, GP40 Protein, Gp38 Protein, HT1A-1 Protein, OTS8 Protein, PA2.26 Protein, T1A Protein, T1A-2 Protein, OTS-8 Protein, RANDAM-2 Protein, T1-alpha Protein, T1a Protein, T1alpha Protein, E11 Protein, RTI40 Protein, podoplanin Protein, PDPN Protein, Pdpn Protein
    Hintergrund
    Podoplanin, also known as glycoprotein 36 (gp36), PA2.26 antigen, T1-alpha (T1A), and aggrus, is a 36 kDa type I transmembrane sialoglycoprotein and member of the Podoplanin family. Podoplanin has three potential splice variants, the longest of which is represented by a 238 amino acid precursor (NP_006465). It contains an undefined signal sequence, a 22 aa transmembrane segment (aa 207-228) and a short cytoplasmic tail (aa 229-238). The ECD contains abundant Ser/Thr residues that could serve as potential O-linked glycosylation sites. The cytoplasmic tail contains putative sites for protein kinase C phosphorylation. There are two potential alternate start sites at Met 77 (Swiss Prot #: Q86YL7) and Met 119 (EAW51692) that generate short forms. The 162 aa short form Podoplanin precursor shares 47% aa identity with mouse Podoplanin. Podoplanin is expressed on glomerular epithelial cells (podocytes), type I lung alveolar cells, lymphatic endothelial cells, and numerous tumors, including colorectal tumors, squamous cell carcinomas, testicular seminoma, and brain tumors. One study shows high expression of Podoplanin mRNA in placenta, lung, skeletal muscle, and heart, and weaker levels in brain, kidney, and liver. Podoplanin is the ligand for C-type lectin-like receptor 2 (CLEC-2). Their association is dependent on sialic acid on O-glycans of Podoplanin. Through its association with CLEC-2, Podoplanin induces platelet aggregation and tumor metastasis. Podoplanin is also necessary for lymphatic vessel formation, normal lung cell proliferation and alveolus formation at birth. The recombinant soluble Podoplanin starts with GLST and ends with GLST.
    Synonyms: PDPN, T1A, GP36, GP40, Gp38, OTS8, T1A-2, AGGRUS, HT1A-1, PA2.26
    Molekulargewicht
    13.1 kDa
    Gen-ID
    10630
    NCBI Accession
    NM_001006624, NP_001006625
    UniProt
    Q86YL7
    Pathways
    Dicarboxylic Acid Transport
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