TIE1 Protein (Soluble) (His tag)

Produktnummer ABIN1589958

Produktdetails

Target: TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))

Protein-Typ: Recombinant

Proteineigenschaft: Soluble

Spezies: Maus

Quelle: Insektenzellen

Aufreinigungstag / Konjugat: Dieses TIE1 Protein ist gelabelt mit His tag.

Sequenz: SVDLTLLANL RITDPQRFFL TCVSGEAGAG RSSDPPLLLE KDDRIVRTFP PGQPLYLARN GSHQVTLRGF SKPSDLVGVF SCVGGAGARR TRVLYVHNSP GAHLFPDKVT HTVNKGDTAV LSAHVHKEKQ TDVIWKNNGS YFNTLDWQEA DDGRFQLQLQ NVQPPSSGIY SATYLEASPL GSAFFRLIVR GCGAGRWGPG CVKDCPGCLH GGVCHDHDGE CVCPPGFTGT RCEQACREGR FGQSCQEQCP GTAGCRGLTF CLPDPYGCSC GSGWRGSQCQ EACAPDHFGA DCRLQCQCQN GGTCDRFSGC VCPSGWHGVH CEKSDRIPQI LSMATEVEFN IGTMPRINCA AAGNPFPVRG SMKLRKPDGT MLLSTKVIVE PDRTTAEFEV PSLTLGDSGF WECRVSTSGG QDSRRFKVNV KVPPVPLTAP RLLAKQSRQL VVSPLVSFSG DGPISSVRLH YRPQDSTIAW SAIVVDPSEN VTLMNLKPKT GYNVRVQLSR PGEGGEGGWG PSALMTTDCP EPLLQPWLES WHVEGPDRLR VSWSLPSVPL SGDGFLLRLW DGARGQERRE NISFPQARTA LLTGLTPGTH YQLDVRLYHC TLLGPASPPA HVHLPPSGPP APRHLHAQAL SDSEIQLMWQ HPEAPSGPIS KYIVEIQVAG GSGDPQWMDV DRPEETSIIV RGLNASTRYL FRVRASVQGL GDWSNTVEEA TLGNGLQSED PVRESRATRH HHHHH

Produktmerkmale: Length (AA): 735
Chromosomal location: 4 D2.1, 4 50.0 cM

Anwendungsinformationen

Kommentare:

Soluble Receptors

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: The lyophilized sTIE-1-His is soluble in water and most aqueous buffers and should be reconstituted in PBS to a concentration not lower than 50 μg/mL.

Buffer: PBS

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Lyophilized samples are stable for greater than six months at -20 °C to -70 °C. Reconstituted sTIE-1-His should be stored in working aliquots at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))

Andere Bezeichnung: TIE-1 (TIE1 Produkte)

Synonyme: JTK14 Protein, TIE Protein, D430008P04Rik Protein, tie-1 Protein, tyrosine kinase with immunoglobulin like and EGF like domains 1 Protein, tyrosine kinase with immunoglobulin-like and EGF-like domains 1 Protein, tyrosine-protein kinase receptor Tie-1 Protein, endothelium-specific receptor tyrosine kinase 1 Protein, TIE1 Protein, Tie1 Protein, CpipJ_CPIJ018933 Protein, tie1 Protein

Hintergrund: Recombinant mouse soluble TIE-1 was fused with a 6x His-tag at the C-terminus. The soluble receptor protein consists of the full extracellular domain (Ser22-Ala748). Mouse sTIE-1 monomer has a calculated molecular mass of approximately 79,8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 95 kDa protein in SDS-PAGE under reducing conditions. TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.
Synonyms: Tie1, TIE, tie-1, D430008P04Rik

NCBI Accession: NP_035717, NM_011587

UniProt: Q06806

Pathways: RTK Signalweg