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IL-6 Receptor Protein (C-Term, Extracellular Domain)

IL6R Spezies: Maus Wirt: HEK-293T Cells Recombinant > 97 %, as determined by SDS-PAGE and HPLC
Produktnummer ABIN1684654
  • Target Alle IL-6 Receptor (IL6R) Proteine anzeigen
    IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
    Protein-Typ
    Recombinant
    Proteineigenschaft
    C-Term, Extracellular Domain
    Spezies
    • 17
    • 4
    • 4
    Maus
    Quelle
    • 12
    • 5
    • 3
    • 3
    • 1
    HEK-293T Cells
    Spezifität
    Optimized DNA sequence encoding extracellular domain of mouse IL-6 receptor (CD126) including a C-terminal 6His tag was expressed in HEK293 cells.
    Produktmerkmale
    Recombinant mouse IL-6 receptor (CD126) is a monomer protein consisting of 357 amino acid residue subunits, due to glycosylation migrates as an approximately 60-65 kDa protein on SDS-PAGE.
    Reinheit
    > 97 %, as determined by SDS-PAGE and HPLC
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg(1EU/µg).
    Top Product
    Discover our top product IL6R Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS solution, pH7.2.
    Handhabung
    Avoid repeated freeze/thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    The lyophilized protein is stable for at least years from date of receipt at -20 °C. Upon reconstitution, this cytokine can be stored in working aliquots at - 8 °C for one month, or at -20 °C for six months, with a carrier protein without detectable loss of activity.
    Haltbarkeit
    12-24 months
  • Target
    IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))
    Andere Bezeichnung
    CD126 (IL6R Produkte)
    Synonyme
    IL6R Protein, il-6ra Protein, CD126 Protein, IL-6R-1 Protein, IL-6RA Protein, IL6Q Protein, IL6RA Protein, IL6RQ Protein, gp80 Protein, IL6R1 Protein, Il6ra Protein, IL-6Ralpha Protein, IL-6R Protein, Il6r Protein, interleukin 6 receptor Protein, interleukin 6 receptor, alpha Protein, IL6R Protein, il6r Protein, Il6r Protein, Il6ra Protein
    Hintergrund
    Neurotrophin-3 is found in neurons of the central nervous system. NT-3 is expressed also in muscles and its expression is down-regulated in denervated muscles. Many human gliomas express and secrete NT-3 into the conditioned medium.ome protein domains of NT-3 are identical with those of NGF and BDNF. NT-3 selectively supports the survival of neuronal cell populations. NT-3 has been shown recently to prevent death of cultured embryonic rat spinal motor neurons at picomolar concentrations. NT-3 has been shown to enhance sprouting of corticospinal tract during development and after adult spinal cord lesion. The activities of NT-3 and BDNF are additive in some systems. The biological activities of NT-3 are mediated by a receptor belonging to the trk family of receptors with intrinsic tyrosine-specific protein kinase activity. NT-3 only binds weakly to the trk receptor which is a high-affinity receptor for NGF.
    UniProt
    P22272
    Pathways
    JAK-STAT Signalweg, Autophagie, Growth Factor Binding, Cancer Immune Checkpoints
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