HSPD1 Protein (partial)

Produktnummer ABIN1686691

Produktdetails

Target: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Protein-Typ: Recombinant

Proteineigenschaft: partial

Spezies: Bakterien

Quelle: Escherichia coli (E. coli)

Applikation: Western Blotting (WB), SDS-PAGE (SDS), ELISA, Functional Studies (Func)

Sequenz: EDPYEKIGAE LVKEVAKKTD DVAGDGTTTA TVLAQALVRE GLRNVAAGAN PLGLKRGIEK AVEKVTETLL KGAKEVETKE QIAATAAISA GDQSIGDLIA EAMDKVGNEG VITVEESNTF GLQLELTEGM RFDKGYISGY FVTDPERQEA VLEDPYILLV SSKVSTVKDL LPLXXXXXXX GKPLLIIAED VEGEALSTLV

Spezifität: ~65 kDa

Aufreinigung: Multi-Step Purified

Reinheit: >90%

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

This product has been certified >90% pure using SDS-PAGE analysis.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: Lot specific

Buffer: 10 mM Tris pH 8, 105 mM NaCl, 5 mM EDTA

Lagerung: -20 °C

Referenzen

Sun, Shen, Liu, Tan, Tian, Luo, Lai, Dai, Guo: "Heat shock protein 65 promotes atherosclerosis through impairing the properties of high density lipoprotein." in: Atherosclerosis, Vol. 237, Issue 2, pp. 853-61, (2014) (PubMed).

Adamus, Bonnah, Brown, David: "Detection of autoantibodies against heat shock proteins and collapsin response mediator proteins in autoimmune retinopathy." in: BMC ophthalmology, Vol. 13, pp. 48, (2013) (PubMed).

Antigendetails

Target: HSPD1 (Heat Shock 60kDa Protein 1 (Chaperonin) (HSPD1))

Abstract: HSPD1 Produkte

Synonyme: CPN60 Protein, GROEL Protein, HLD4 Protein, HSP-60 Protein, HSP60 Protein, HSP65 Protein, HuCHA60 Protein, SPG13 Protein, chaperonin Protein, cpn60 Protein, groel Protein, hld4 Protein, hsp60 Protein, hsp65 Protein, spg13 Protein, 60kDa Protein, Hsp60 Protein, 12 Protein, BP5 Protein, CG12101 Protein, Cpn60 Protein, Dmel\\CG12101 Protein, Dmhsp60 Protein, G62 Protein, HSP60A Protein, Hsp60A Protein, IEF16 Protein, Mmp-P1 Protein, SSP 7506 Protein, d-hsp60 Protein, hsp60A Protein, l(1)10Ac Protein, l(1)BP5 Protein, l(1)G8 Protein, l(1)HM21 Protein, l(1)L12 Protein, l(1)dp025 Protein, cb863 Protein, fa04a05 Protein, fb22d10 Protein, fi27b05 Protein, id:ibd2197 Protein, sb:cb144 Protein, wu:fa04a05 Protein, wu:fb22d10 Protein, wu:fi04a12 Protein, wu:fi27b05 Protein, MIF4 Protein, MNA2 Protein, mopA Protein, groL Protein, crpA Protein, Hspd1-30p Protein, heat shock protein family D (Hsp60) member 1 Protein, heat shock protein family D (Hsp60) member 1 S homeolog Protein, 60 kDa heat shock protein, mitochondrial Protein, heat shock protein 1 (chaperonin) Protein, Heat shock protein 60A Protein, heat shock 60 protein 1 Protein, chaperone ATPase HSP60 Protein, molecular chaperone GroEL Protein, thermosome subunit Protein, chaperonin GroEL Protein, mitochondrial chaperonin Protein, heat shock protein family D member 1 Protein, HSPD1 Protein, hspd1.S Protein, hspd1 Protein, LOC100414401 Protein, Hspd1 Protein, Hsp60A Protein, HSP60 Protein, groEL Protein, MMP_RS07785 Protein, groEl Protein, LOC100136430 Protein

Hintergrund: HSP65 isolated from Mycobacterium bovis BCG, is a member of the HSP60 family of heat shock proteins (2, 3). HSP60s are mitochondrial chaperonins that are typically held responsible for the transportation and refolding of proteins from the cytoplasm into the mitochondrial matrix. In addition to its role as a heat shock protein, HSP60 functions as a chaperonin to assist in folding linear amino acid chains into their respective three-dimensional structure. HSP60s are a ubiquitous class of HSPs that specifically promote the folding and assembly of cellular polypeptides in an ATP-dependent manner (1). Specifically, sequence comparison of HSP65 from different mycobacterium strains showed that the protein sequence of M. bovis BCG is identical to that of M. tuberculosis, and very similar to that of M. leprae, the pathogens that cause tuberculosis and tuberculoid leprosy, respectively (2,4). Mycobacterium bovis BCG HSP65 was identified as the immunodominant antigen during mycobacterial diseases and vaccination. It is also believed to be the antigen that induces autoimmune disease, such as adjuvant arthritis in rats (5, 6).

Molekulargewicht: approx. 65 kDa

UniProt: Q1EHB9

Pathways: Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity