Complement C4 Protein

Produktnummer ABIN1880330

Produktdetails

Target: Complement C4 (C4) (Complement 4 (C4))

Protein-Typ: Native

Spezies: Human

Quelle: Human

Aufreinigung: Purified

Reinheit: > 90 % by SDS-PAGE

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10mM PBS (pH 7.4).

Lagerung: 4 °C

Antigendetails

Target: Complement C4 (C4) (Complement 4 (C4))

Andere Bezeichnung: Complement C4 (C4 Produkte)

Synonyme: C4B1 Protein, C4B12 Protein, C4B2 Protein, C4B3 Protein, C4B5 Protein, C4BD Protein, C4B_2 Protein, C4F Protein, CH Protein, CO4 Protein, CPAMD3 Protein, C4 Protein, C4A2 Protein, C4A3 Protein, C4A4 Protein, C4A6 Protein, C4AD Protein, C4S Protein, CPAMD2 Protein, RG Protein, C4-1 Protein, C4b Protein, C4-2 Protein, Slp Protein, Ss Protein, complement C4B (Chido blood group) Protein, complement C4A (Rodgers blood group) Protein, complement component 4A (Rodgers blood group) Protein, complement 4 Protein, complement component 4A Protein, complement component 4B (Chido blood group) Protein, C4B Protein, C4A Protein, C4a Protein, C4 Protein, C4b Protein

Hintergrund: Complement C4 encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [

Pathways: Komplementsystem