IFN alpha 2b Protein
Spezies: Human
Wirt: Escherichia coli (E. coli)
Recombinant
> 95 % by SDS-PAGE
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- Target Alle IFN alpha 2b Produkte
- IFN alpha 2b
- Protein-Typ
- Recombinant
- Spezies
- Human
-
Quelle
- Escherichia coli (E. coli)
- Reinheit
- > 95 % by SDS-PAGE
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IFN alpha 2b (AA 24-188) (Active) protein (Fc Tag)
Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Reconstitute with sterile 18 mΩ/cm^3 H2O.
- Buffer
- 10 mM Phosphate buffer and 200 mM NaCl (pH 7.0)
- Konservierungsmittel
- Without preservative
- Lagerung
- 4 °C
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- Target
- IFN alpha 2b
- Abstract
- IFN alpha 2b Produkte
- Synonyme
- IFN-alphaA Protein, IFNA Protein, IFNA2B Protein, INFA2 Protein, interferon alpha 2 Protein, IFNA2 Protein
- Hintergrund
- IFN-alpha, a multifunctional cytokine important in the innate immune system, has been proposed to play a major pathogenic role in the development of systemic lupus erythematosus in humans and mice. IFNA bound complement component receptor-2 (CR2) in the same affinity range as other CR2 ligands. Asokan et al. (2006) proposed that the roles of CR2 and IFNA in development of autoimmunity may be mechanistically linked to pathogenesis of systemic lupus erythematosus. Interferon-alpha and -beta (IFN-alpha/beta) and the tumour suppressor p53 are essential for the induction of apoptosis in cancerous cells and in antiviral immune responses, respectively. The transcription of the p53 gene is induced by IFN-alpha/beta, accompanied by an increase in p53 protein level. IFN-alpha/beta signalling itself does not activate p53, rather, it contributes to boosting p53 responses to stress signals.
- Molekulargewicht
- 19.2 +/- 1.9 kDa
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