Recombinant Human 2-oxoglutarate dehydrogenase, mitochondrial/OGDH is produced with our mammalian expression system in human cells. The target protein is expressed with sequence (AA 41-1023) of Human OGDH fused with a polyhistidine tag at the C-termin
Crystallography grade
alphaKGDHC
Spezies: Human
Wirt: Insektenzellen
Recombinant
>95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
SDS, WB, ELISA, Crys
OGDH, also known as 2-oxoglutarate dehydrogenase complex component E1 or Alpha-ketoglutarate dehydrogenase, is short for 2-oxoglutarate dehydrogenase, mitochondrial. It is a 1023 aa. protein, the first 40 aa. of which is a transit peptide. OGDH is usually located in the mitochondrion, and belongs to the pha-ketoglutarate dehydrogenase family. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).