CCL11 Protein

Produktnummer ABIN7477969

Produktdetails

Target: CCL11 (Chemokine (C-C Motif) Ligand 11 (CCL11))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Maus

Quelle: Escherichia coli (E. coli)

Sequenz: HPGSIPTSCC FIMTSKKIPN TLLKSYKRIT NNRCTLKAIV FKTRLGKEIC ADPKKKWVQD ATKHLDQKLQ TPKP

Produktmerkmale: Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using purified eosinophils is in a concentration range of 100-1000 ng/mL.

Reinheit: > 96 % by SDS-PAGE and HPLC analyses.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1 EU/μg of rMuEotaxin/CCL11 as determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.

Buffer: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C.

Antigendetails

Target: CCL11 (Chemokine (C-C Motif) Ligand 11 (CCL11))

Andere Bezeichnung: Eotaxin/CCL11 (CCL11 Produkte)

Synonyme: SCYA11 Protein, Scya11 Protein, eotaxin Protein, Eotaxin Protein, C-C motif chemokine ligand 11 Protein, chemokine (C-C motif) ligand 11 Protein, CCL11 Protein, Ccl11 Protein

Hintergrund: Eotaxin also called CCL11 is a CC chemokine that signals through the CCR3 receptor. It is produced by IFN-gamma stimulated endothelial cells and TNF-activated monocytes. Eotaxin selectively chemoattracts eosinophils and along Eotaxin-2 and Eotaxin-3, plays a key role in the regulation of eosinophil recruitment in the asthmatic lung, and in allergic reactions.
Synonyms: Eotaxin murine, CCL11 murine

Molekulargewicht: 8.4 kDa, a single non-glycosylated polypeptide chain containing 74 amino acids.

Pathways: Regulation of Actin Filament Polymerization, Phosphorylierungen bei SARS-CoV-2 Infektion