FGF4 Protein (AA 31-206)

Produktnummer ABIN2017823

Produktdetails

Target: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 31-206

Spezies: Human

Quelle: Escherichia coli (E. coli)

Produktmerkmale: ED50<0.5 ng/mL, measured in a cell proliferation assay using 3T3 cells, corresponding to a specific activity of >2.0× 10^6 units/mg
AA 31-206, expressed with an N-terminal Met.

Reinheit: > 95 % by SDS-PAGE and HPLC analyses.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against 50 mM HEPES, 750 mM NaCl, pH 7.5.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant human Fibroblast Growth Factor-4 (rhFGF-4) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhFGF-4 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.

Haltbarkeit: 6 months

Antigendetails

Target: FGF4 (Fibroblast Growth Factor 4 (FGF4))

Andere Bezeichnung: Fibroblast Growth Factor-4 (FGF-4) (FGF4 Produkte)

Hintergrund: Fibroblast Growth Factor-4 (FGF-4) also known as K-FGF is a heparin-binding growth factor of the FGF family.It was identified by its oncogenic transforming activity. FGF-4 and FGF-3 are located closely on chromosome 11. FGF-4 and its receptors (FGF R1c, 2c, 3c and 4) play an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. FGF-4 is required for normal limb and cardiac valve development during embryogenesis. Recombinant human Fibroblast Growth Factor-4 (rhFGF-4) produced in E. coli is a single non-glycosylated polypeptide chain containing 177 amino acids. A fully biologically active molecule obtained by proprietary chromatographic techniques, rhFGF-4 has a molecular mass of 19.4 kDa as analyzed by reducing SDS-PAGE.
Synonyms: HBGF-4, HST, HST-1, HSTF1, K-FGF, KFGF.

Molekulargewicht: 19.4kDa, observed by reducing SDS-PAGE.

UniProt: P08620

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance