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Growth Hormone 1 Protein (GH1) (AA 27-217)

GH1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE and HPLC analyses. Active
Produktnummer ABIN2017922
  • Target Alle Growth Hormone 1 (GH1) Proteine anzeigen
    Growth Hormone 1 (GH1)
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 27-217
    Spezies
    • 12
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Quelle
    • 67
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    Escherichia coli (E. coli)
    Produktmerkmale
    ED50 < 0.5 ng/mL, measured by a cell proliferation assay using Nb2-11 Cells, corresponding to a specific activity of > 2.0x 10^6 units/mg.
    Reinheit
    > 95 % by SDS-PAGE and HPLC analyses.
    Endotoxin-Niveau
    < 0.2 EU/μg, determined by LAL method.
    Top Product
    Discover our top product GH1 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstituted in ddH2O at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Lyophilized recombinant human Growth Hormone (rhGH) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhGH should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    Haltbarkeit
    6 months
  • Basu, Nahar, Kulkarni, Kerekes, Sattler, Hall, Neggers, Holub, Kopchick: "A novel peptide antagonist of the human growth hormone receptor." in: The Journal of biological chemistry, pp. 100588, (2021) (PubMed).

    Qian, Basu, Mathes, Arnett, Duran-Ortiz, Funk, Brittain, Kulkarni, Terry, Davis, Singerman, Henry, List, Berryman, Kopchick: "Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo." in: Cancers, Vol. 12, Issue 12, (2020) (PubMed).

    Basu, Baumgaertel, Wu, Kopchick: "Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps." in: Hormones & cancer, Vol. 8, Issue 3, pp. 143-156, (2018) (PubMed).

  • Target
    Growth Hormone 1 (GH1)
    Andere Bezeichnung
    Growth Hormone (GH) (GH1 Produkte)
    Synonyme
    GH Protein, GH-N Protein, GHN Protein, IGHD1B Protein, hGH-N Protein, Gh1 Protein, GH1 Protein, gh Protein, Gh Protein, GH2 Protein, RNGHGP Protein, ghl Protein, gh-n Protein, ghn Protein, ighd1b Protein, gh1 Protein, ghb-A Protein, GHI Protein, GHB3 Protein, growth hormone 1 Protein, growth hormone Protein, somatotropin-like Protein, somatotropin Protein, growth hormone prepeptide Protein, growth hormone 1 L homeolog Protein, growth hormone 1 S homeolog Protein, Somatotropin-1 Protein, GH1 Protein, Gh Protein, GH Protein, LOC100305005 Protein, Gh1 Protein, LOC100534452 Protein, LOC100232594 Protein, LOC100303681 Protein, gh1 Protein, LOC100356068 Protein, LOC100136588 Protein, gh1.L Protein, gh1.S Protein, LOC109081196 Protein
    Hintergrund
    Growth Hormone (GH) is a member of the somatotropin/prolactin family which play an important role in growth control. The human GH cDNA encodes a 217 amino acid (aa), and the first 26 aa is a signal peptide. By alternative splicing, at least four isoforms of GH have been identified. The major role of GH in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. GH stimulates both the differentiation and proliferation of myoblasts, and also stimulates amino acid uptake and protein synthesis in muscle and other tissues.Recombinant human Growth Hormone (rhGH) produced in E. coli is a single non-glycosylated polypeptide chain containing 191 amino acids. A fully biologically active molecule, rhGH has a molecular mass of 22.1 kDa analyzed by reducing SDS-PAGE.
    Synonyms: GH1, GH, GHN, GH-N, hGH-N,Pituitary growth hormone, Growth hormone 1, Somatotropin
    Molekulargewicht
    22.1 kDa, observed by reducing SDS-PAGE.
    UniProt
    P01241
    Pathways
    NF-kappaB Signalweg, JAK-STAT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Response to Growth Hormone Stimulus, Regulation of Hormone Biosynthetic Process
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