Interleukin 17a Protein (AA 20-155) (His tag)

Produktnummer ABIN2018066

Produktdetails

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 20-155

Spezies: Human

Quelle: CHO Cells

Aufreinigungstag / Konjugat: Dieses Interleukin 17a Protein ist gelabelt mit His tag.

Produktmerkmale: ED50 < 0.3 ng/mL, measured in a bioassay using NHDF cells, corresponding to a specific activity of > 3.3x10^6 units/mg.
AA 20-155 expressed with C-terminal 6xHis.

Reinheit: > 95 % as analyzed by SDS-PAGE.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant humanInterleukin-17A (IL-17A), His remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, human Interleukin-17A (IL-17A), His should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Andere Bezeichnung: Interleukin-17A (IL-17A) (IL17A Produkte)

Synonyme: CTLA8 Protein, IL-17 Protein, IL-17A Protein, IL17 Protein, Ctla-8 Protein, Ctla8 Protein, Il17 Protein, ChIL-17 Protein, IL-17F Protein, IL17A Protein, CTLA-8 Protein, interleukin 17A Protein, IL17A Protein, Il17a Protein

Hintergrund: Interleukin-17A (IL-17A),also known as CTLA-8 and IL-17, is a proinflammatory cytokine belonging to the IL-17 family. It is secreted by Th17 cells, gamma/delta T cells, NK cells and neutrophils. IL-17A signals through IL-17 receptor A in a complex with receptor C or D to regulate NF-kappaB and MAP kinase activities. IL-17A plays important roles in the anti-microbial response and chronic inflammation. It stimulates the production of IL-6, IL-8 and G-CSF in epithelial and endothelial cells, and induces the expression of ICAM-1 in fibroblasts. Clinically, IL-17A has been associated with inflammatory diseases, such as rheumatoid arthritis, psoriasis and multiple sclerosis.Recombinant human Interleukin-17A (rhIL-17A) produced in CHO cells is a glycosylated homodimer chain containing 142 amino acids. A fully biologically active molecule, rhIL-17A has a molecular mass of around 14-22 kDa analyzed by reducing SDS-PAGE.
Synonyms:

Molekulargewicht: 14-22 kDa, observed by reducing SDS-PAGE.