IL-33 Protein (AA 112-270)
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- Target Alle IL-33 (IL33) Proteine anzeigen
- IL-33 (IL33) (Interleukin 33 (IL33))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 112-270
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Spezies
- Human
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Quelle
- Escherichia coli (E. coli)
- Produktmerkmale
- ED50 <0.5 ng/mL, measured by a cell proliferation assay using D10S cells, corresponding to a specific activity of > 2× 10^6 units/mg.
- Reinheit
- > 95 % by SDS-PAGEanalysis.
- Endotoxin-Niveau
- < 0.2 EU/μg, determined by LAL method.
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Interleukin 33 (IL33) (AA 112-270) protein
IL33 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 33 (IL33) (AA 109-270) (Active) protein (His tag)IL33 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Interleukin 33 (IL33) (AA 109-270) protein (His tag)IL33 Spezies: Cynomolgus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Interleukin 33 (IL33) (AA 109-264) protein (His tag)IL33 Spezies: Ratte Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Interleukin 33 (IL33) (AA 1-270) protein (GST tag)IL33 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Interleukin 33 (IL33) (AA 171-269) protein (GST tag)IL33 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Interleukin 33 (IL33) protein (His tag)IL33 Spezies: Rhesusaffen Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by reducing SDS-PAGE.
Interleukin 33 (IL33) (AA 109-270) (Active) protein (His tag)IL33 Spezies: Cynomolgus Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Rekonstitution
- Reconstituted in ddH2O at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Lagerung
- -80 °C
- Informationen zur Lagerung
- Lyophilized recombinant human Interleukin-33 (rhIL-33) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhIL-33 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Haltbarkeit
- 6 months
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- Target
- IL-33 (IL33) (Interleukin 33 (IL33))
- Andere Bezeichnung
- Interleukin-33 (IL-33) (IL33 Produkte)
- Hintergrund
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Interleukin-33 (IL-33) is a proinflammatory cytokine that belongs to the IL-1 family. IL-33 is expressed in a variety of cells, including epithelial and endothelial cells, smooth muscle cells, macrophages and fibroblasts. The primary receptors for IL-33 are ST2 and IL-1 receptor accessory protein (IL-1RAcP), both of which belong to the IL-1 receptor family. IL-33 is localized to the nucleus of resting cells where it binds to chromatin in the H2A-H2B histone complex as a transcriptional suppressor. IL-33 is secreted by cells during injury which induces a T-helper 2 type inflammatory response. Evidence suggests IL-33 plays a role in autoimmune disease. IL-33's interaction with ST2 can drive allergic pathology and IL-33 has been reported to play a role in the development of rheumatoid arthritis and systemic lupus erythematosus.Recombinant humanInterleukin-33 (rhIL-33) produced in E. coli is a single non-glycosylated polypeptide chain containing 159 amino acids. A fully biologically active molecule, rhIL-33 has a molecular mass of 18.0 kDa analyzed by reducing SDS-PAGE.
Synonyms: IL-1F11, NF-HEV - Molekulargewicht
- 18.0 kDa, observed by reducing SDS-PAGE.
- UniProt
- O95760
- Pathways
- Production of Molecular Mediator of Immune Response
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