SERPINB5
Spezies: Human
Wirt: Tobacco (Nicotiana tabacum)
Recombinant
>80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
WB, SDS, ELISA
Lyophilized recombinant human Maspin (rhMaspin) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhMaspin remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
Haltbarkeit
6 months
Target
SERPINB5
(serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 (SERPINB5))
1110036M19Rik Protein, AI462524 Protein, AI646751 Protein, Maspin Protein, PI-5 Protein, Spi7 Protein, ovalbumin Protein, PI5 Protein, maspin Protein, Pi5 Protein, serine (or cysteine) peptidase inhibitor, clade B, member 5 Protein, serpin family B member 5 Protein, serpin peptidase inhibitor, clade B (ovalbumin), member 5 S homeolog Protein, Serpinb5 Protein, SERPINB5 Protein, serpinb5.S Protein
Hintergrund
Maspin is a non-inhibitory member of the serpin superfamily, a group of 40-60 kDa serine protease inhibitors. Maspin was discovered in 1994 and has been identified in prostate, thymus, testis, intestine, tongue, and lung. Recently Maspin received a great deal of attention due to its potential apoptotic role in cancers. Maspin expression predicts a better prognosis for several types of carcinomas including breast, prostate, colon, and oral squamus cell carcinoma. The level of Maspin is also inversely correlated to VEGF-A, an angiogenic factor. Researchers found that Maspin may play its apoptotic role as an endogenous inhibitor of histone deacetylase I (HDAC I). Therefore, Maspin is a potential personalized marker of Non-Small Cell Lung Carcinoma (NSCLC).Recombinant human Maspin (rhMaspin) produced in E. coli is a single non-glycosylated polypeptide chain containing 375 amino acids. rhMaspin has a molecular mass of 42.1 kDa analyzed by reducing SDS-PAGE. Synonyms: Serpin B5, PI-5