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CCL15 Protein (AA 22-113, Ile24Thr-Mutant)

CCL15 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis. Active
Produktnummer ABIN2018260
  • Target Alle CCL15 Proteine anzeigen
    CCL15 (Chemokine (C-C Motif) Ligand 15 (CCL15))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 22-113, Ile24Thr-Mutant
    Spezies
    Human
    Quelle
    • 6
    • 2
    • 2
    Escherichia coli (E. coli)
    Produktmerkmale
    ED50 < 2 μg/mL, measured by the FLIPR assay using CHO cells transfected with human CCR1, the receptor of human CCL15, corresponding to a specific activity of > 500 units/mg.
    Reinheit
    > 95 % by SDS-PAGE analysis.
    Endotoxin-Niveau
    < 0.2 EU/μg, determined by LAL method.
    Top Product
    Discover our top product CCL15 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstituted in ddH2O at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Lyophilized recombinant human MIP-5/CCL15 (rhMIP-5/CCL15) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhMIP-5/CCL15 remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    Haltbarkeit
    6 months
  • Target
    CCL15 (Chemokine (C-C Motif) Ligand 15 (CCL15))
    Andere Bezeichnung
    MIP-5 /CCL15 (CCL15 Produkte)
    Synonyme
    HCC-2 Protein, HMRP-2B Protein, LKN-1 Protein, LKN1 Protein, MIP-1 delta Protein, MIP-1D Protein, MIP-5 Protein, MRP-2B Protein, NCC-3 Protein, NCC3 Protein, SCYA15 Protein, SCYL3 Protein, SY15 Protein, C-C motif chemokine ligand 15 Protein, CCL15 Protein
    Hintergrund
    Macrophage Inflammatory Protein-5 (MIP-5/CCL15) is a chemokine originally identified in the human hemofiltrate, thus it is also named Hemofiltrate CC Chemokine-2 (HCC-2). MIP-5 belongs to the CCL chemokine family, and its receptors are G-protein coupled receptors CCR1 and CCR3, with CCR1 being the major one. MIP-5 is mainly expressed in heart and skeletal muscle, and CCR1 is expressed on Th1 and Th2 cells in human cord blood lymphocytes. In vivo, MIP-5 promotes the accumulation of immature myeloid cells and the expansion of metastatic foci in the lever. MIP-5 contributes to severe asthma, sarcoidosis, and atherosclerosis,however, MIP-5 can also inhibit stem cell proliferation, implicating its therapeutic potential as an alternative to high dose chemotherapy.Recombinant human MIP-5/CCL15 (rhMIP-5/CCL15) produced in E.coli is a single non-glycosylated polypeptide chain containing 92 amino acids. A fully biologically active molecule, rhMIP-5/CCL15 has a molecular mass of 10.2 kDa analyzed by reducing SDS-PAGE.
    Synonyms: HCC-2, LKN-1, MIP-1 delta
    Molekulargewicht
    10.2 kDa, observed by reducing SDS-PAGE.
    UniProt
    Q16663
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