Oncostatin M Protein (OSM) (AA 26-239)

Produktnummer ABIN2018303

Produktdetails

Target: Oncostatin M (OSM)

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 26-239

Spezies: Ratte

Quelle: Escherichia coli (E. coli)

Produktmerkmale: ED50 < 10 ng/mL, measured by a cell proliferation assay using Rat Embryo Brain cells, corresponding to a specific activity of > 1x 10^5 units/mg.
AA 26-239, expressed with an N-terminal Met.

Reinheit: > 95 % as analyzed by SDS-PAGE and HPLC.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant Rat Oncostatin M (rrOSM) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rrOSM remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: Oncostatin M (OSM)

Andere Bezeichnung: Oncostatin M(OSM) (OSM Produkte)

Synonyme: OSM Protein, OncoM Protein, oncostatin M Protein, OSM Protein, Osm Protein

Hintergrund: Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor beta or LIF Receptor beta to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant Mouse Oncostatin M (rmOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 182 amino acids. A fully biologically active molecule, rmOSM has a molecular mass of 20.5 kDa analyzed by reducing SDS-PAGE.
Synonyms: OSM

Molekulargewicht: 24.5 kDa, observed by reducing SDS-PAGE.

UniProt: Q65Z15

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion