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Otoraplin Protein (OTOR) (AA 18-128)

OTOR Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis.
Produktnummer ABIN2018309
  • Target Alle Otoraplin (OTOR) Proteine anzeigen
    Otoraplin (OTOR)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 18-128
    Spezies
    • 2
    • 1
    • 1
    • 1
    Human
    Quelle
    • 2
    • 2
    • 1
    Escherichia coli (E. coli)
    Produktmerkmale
    AA 18-128, expressed with an N-terminal Met.
    Reinheit
    > 95 % by SDS-PAGE analysis.
    Endotoxin-Niveau
    < 0.2 EU/μg, determined by LAL method.
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstituted in ddH2O at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Lyophilized recombinant human Otoraplin (rhOTOR) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhOTOR remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
    Haltbarkeit
    6 months
  • Target
    Otoraplin (OTOR)
    Abstract
    OTOR Produkte
    Synonyme
    FDP Protein, MIAL1 Protein, CDRAP Protein, Fdp Protein, MIA Protein, MIAL Protein, MGC133655 Protein, MGC86203 Protein, otoraplin Protein, otoraplin L homeolog Protein, OTOR Protein, Otor Protein, otor.L Protein, otor Protein
    Hintergrund
    Otoraplin (OTOR) is a cytokine first identified in 2000 and encodes a small protein of 128 amino acids with an SH3 domain. OTOR is a homologue to CD-RAP/MIA and contains a hydrophobic N-terminal region as a signal peptide, which indicates that OTOR is mainly secreted. Researchers found that high expression of OTOR is only seen in the cochlea, demonstrating its importance in hearing. Indeed, loss of the gene produces cochlear dysfunction and otosclerosis, a hearing disorder involving the bony tissue of the ear. OTOR exerts an influence on the surrounding otic capsule and functions in the extracellular matrix of the membranous portion of the cochlea. Recombinant human Otoraplin (rhOTOR) produced in E. coli is a single non-glycosylated polypeptide chain containing 112 amino acids. rhOTOR has a molecular mass of 12.7 kDa analyzed by reducing SDS-PAGE.
    Synonyms: FDP, MIAL
    Molekulargewicht
    12.7 kDa, observed by reducing SDS-PAGE.
    UniProt
    Q9NRC9
    Pathways
    Sensory Perception of Sound, Regulation of Carbohydrate Metabolic Process
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