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PF4 Protein (AA 32-101)

PF4 Spezies: Human Wirt: HEK-293T Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active
Produktnummer ABIN2018316
  • Target Alle PF4 Proteine anzeigen
    PF4 (Platelet Factor 4 (PF4))
    Protein-Typ
    Recombinant
    Biologische Aktivität
    Active
    Proteineigenschaft
    AA 32-101
    Spezies
    • 16
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Quelle
    • 25
    • 4
    • 4
    • 2
    • 2
    • 1
    HEK-293T Cells
    Produktmerkmale
    ED50 < 10 μg/mL, measured by its ability to inhibit human FGF-basic-dependent proliferation of NR6R 3T3 mouse fibroblast cells.
    Reinheit
    > 95 % as analyzed by SDS-PAGE and HPLC.
    Endotoxin-Niveau
    < 0.2 EU/μg, determined by LAL method.
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  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Reconstituted in ddH2O or PBS at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Lagerung
    -80 °C
    Informationen zur Lagerung
    Lyophilized recombinant human platelet factor 4 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, human platelet factor 4 should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
    Haltbarkeit
    6 months
  • Target
    PF4 (Platelet Factor 4 (PF4))
    Andere Bezeichnung
    Platelet Factor 4/CXCL4 (PF4 Produkte)
    Synonyme
    CXCL4 Protein, PF-4 Protein, SCYB4 Protein, Cxcl4 Protein, Scyb4 Protein, Pf4a Protein, RATPF4A Protein, PF4A Protein, CXCL4L1 Protein, CXCL4V1 Protein, PF4-ALT Protein, SCYB4V1 Protein, PF4 Protein, platelet factor 4 Protein, platelet factor 4 variant 1 Protein, PF4 Protein, Pf4 Protein, LOC703451 Protein, PF4V1 Protein, LOC100524373 Protein, LOC102181854 Protein, LOC100630489 Protein
    Hintergrund
    Platelet factor 4, also known as CXCL4, is expressed in megakaryocytes and stored in the alpha-granules of platelets. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. Platelet factor 4 can be antiproliferative and antiangiogenic, at least in part via interfering with FGF2 and VEGF heparin binding and thus inhibiting their signaling. However, it can also be proinflammatory and proatherogenic through multiple effects on monocytes, macrophages and endothelial cells.
    Synonyms: PF-4, CXCL4, SCYB4,Platelet Factor-4, CXCL4, Oncostatin A, Ironplact
    Molekulargewicht
    -7.8 kDa, observed by non-reducing SDS-PAGE.
    UniProt
    P02776
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