VEGFC Protein (AA 102-227)

Produktnummer ABIN2018451

Produktdetails

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 102-227

Spezies: Human

Quelle: HEK-293T Cells

Produktmerkmale: Measured in a cell proliferation assay using HMVEC human microvascular endothelial cells. The ED50 for this effect is < 0.5 μg/mL.
AA 102-227 with an N-terminal Met.

Reinheit: > 95 % as analyzed by SDS-PAGE.

Endotoxin-Niveau: < 0.2 EU/μg, determined by LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Buffer: Lyophilized after extensive dialysis against PBS.

Lagerung: -80 °C

Informationen zur Lagerung: Lyophilized recombinant Human Vascular Endothelial Growth Factor C remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Human Vascular Endothelial Growth Factor C should be stable up to 1 week at 4 °C or up to 3 months at -20 °C.

Haltbarkeit: 6 months

Antigendetails

Target: VEGFC (Vascular Endothelial Growth Factor C (VEGFC))

Andere Bezeichnung: Vascular Endothelial Growth Factor C (VEGF-C) (VEGFC Produkte)

Synonyme: VEGFC Protein, vegf-c Protein, xvegf-c Protein, Flt4-L Protein, VRP Protein, AW228853 Protein, VEGF-C Protein, vascular endothelial growth factor c Protein, vascular endothelial growth factor C Protein, vascular endothelial growth factor C S homeolog Protein, vegfc Protein, VEGFC Protein, vegfc.S Protein, Vegfc Protein

Hintergrund: Vascular endothelial growth factor C (VEGF-C) is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis, lymphangiogenesis and endothelial cell growth and survival, and can also affect the permeability of blood vessels. VEGF-C is expressed in various tissues, however it is not produced in peripheral blood lymphocytes. It forms cell surface-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. The structure and function of VEGF-C is similar to those of vascular endothelial growth factor D (VEGF-D).Recombinant human VEGF-C produced in HEK293 cells is a polypeptide chain containing 126 amino acids. A fully biologically active molecule, rhVEGF-C has a molecular mass of 16-19 kDa analyzed by reducing SDS-PAGE.
Synonyms: Flt4 ligand, VRP

Molekulargewicht: 16-19 kDa, observed by reducing SDS-PAGE.

UniProt: P14844

Pathways: RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2