IL6RA Protein

Produktnummer ABIN2130109

Produktdetails

Target: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Spezies: Human

Quelle: HEK-293 Cells

Sequenz: LAPRRCPAQE VARGVLTSLP GDSVTLTCPG VEPEDNATVH WVLRKPAAGS HPSRWAGMGR RLLLRSVQLH DSGNYSCYRA GRPAGTVHLL VDVPPEEPQL SCFRKSPLSN VVCEWGPRST PSLTTKAVLL VRKFQNSPAE DFQEPCQYSQ ESQKFSCQLA VPEGDSSFYI VSMCVASSVG SKFSKTQTFQ GCGILQPDPP ANITVTAVAR NPRWLSVTWQ DPHSWNSSFY RLRFELRYRA ERSKTFTTWM VKDLQHHCVI HDAWSGLRHV VQLRAQEEFG QGEWSEWSPE AMGTPWTESR SPPAENEVST PMQALTTNKD DDNILFRDSA NATSLPVQD

Produktmerkmale: Purified recombinant Human IL6 R alpha protein
Expression System: HEK cells
Bioactivity: The ED50 was determined by its ability to intensify the IL-6 induced growth inhibition of Mouse M1 cells is ? 5.0 ng/mL, in the presence of 20 ng/mL of rhIL-6.

Reinheit: > 98 % pure

Endotoxin-Niveau: < 0.1 ng per μg (1 EU/μg).

Anwendungsinformationen

Applikationshinweise: Each Investigator should determine their own optimal working dilution for specific applications.

Kommentare:

Biological activity: The ED50 was determined by its ability to intensify the IL-6 induced growth inhibition of Mouse M1 cells is approx. 5.0 ng/mL, in the presence of 20 ng/mL of rhIL-6.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 1 PBS to a concentration of 0.1-1.0 mg/mL. When dissolved, dilute further into aqueous buffered solutions.

Buffer: Lyophilized from 1x PBS.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: RT/-20 °C

Antigendetails

Target: IL6RA (Interleukin 6 Receptor, alpha (IL6RA))

Andere Bezeichnung: IL6R alpha (IL6RA Produkte)

Synonyme: IL6R1 Protein, Il6ra Protein, CD126 Protein, IL-6R-1 Protein, IL-6RA Protein, IL6Q Protein, IL6RA Protein, IL6RQ Protein, gp80 Protein, IL-6R Protein, Il6r Protein, interleukin 6 receptor Protein, interleukin 6 receptor, alpha Protein, Il6r Protein, IL6R Protein, Il6ra Protein

Hintergrund: IL6 mediates its biological effects through the type I IL6 receptor system that consists of two chains, IL6Ra and gp130. The IL6Ra chain is the binding component specific to IL6, while the gp130 only transmits signals of IL6 when bound to IL6Ra. The gp130 also can transmit signals from LIF, OSM, CNTF, IL11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL6 is composed of IL6Ra alone. IL6Ra is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL6Ra which consists of only the extracellular domain of the IL6Ra chain, acts as an agonist of IL6 activity at low concentrations.
Alternative Names: B cell stimulatory factor-2 protein, soluble IL-6 receptor alpha protein, IL-6, IL6, Interleukin 6R alpha protein, CD126 protein, IL-6R alpha protein, IL-6 protein, IL 6 protein, IL 6

Molekulargewicht: 37.6 kDa

Pathways: JAK-STAT Signalweg, Autophagie, Growth Factor Binding, Cancer Immune Checkpoints