Dieses Growth Hormone Receptor Protein ist gelabelt mit His tag.
Sequenz
AA 27-264
Produktmerkmale
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.5 kDa. The protein migrates as 40-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
GHR
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
GHR
Spezies: Rhesusaffen
Wirt: HEK-293 Cells
Recombinant
>90 % as determined by SDS-PAGE.
Active
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
PBS, pH 7.4
Handhabung
Please avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Ko, Chandra, Ouyang, Kwon, Karande, Han: "Nanofluidic device for continuous multiparameter quality assurance of biologics." in: Nature nanotechnology, Vol. 12, Issue 8, pp. 804-812, (2019) (PubMed).
Nelson, Kim, Reuel, Salem, Bisker, Landry, Kruss, Barone, Kwak, Strano: "Mechanism of immobilized protein A binding to immunoglobulin G on nanosensor array surfaces." in: Analytical chemistry, Vol. 87, Issue 16, pp. 8186-93, (2015) (PubMed).
Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.