Growth Hormone Receptor Protein (GHR) (AA 27-264) (His tag,Biotin)
-
- Target Alle Growth Hormone Receptor (GHR) Proteine anzeigen
- Growth Hormone Receptor (GHR)
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
- Proteineigenschaft
- AA 27-264
-
Spezies
- Human
-
Quelle
- HEK-293 Cells
- Aufreinigungstag / Konjugat
- Dieses Growth Hormone Receptor Protein ist gelabelt mit His tag,Biotin.
- Marke
- MABSol®,UltraLys
- Sequenz
- AA 27-264
- Spezifität
- The primary amines in the side chains of lysine residues and the N-terminus of the protein are conjugated with biotins using standard chemical labeling method. A standard biotin reagent (13.5 angstroms) is used in this product.
- Produktmerkmale
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.5 kDa. The protein migrates as 40-60 kDa on a SDS-PAGE gel under reducing (R) condition due to glycosylation.
- Reinheit
- >90 % as determined by reduced SDS-PAGE.
- Sterilität
- 0.22 μm filtered
- Endotoxin-Niveau
- Less than 1.0 EU per μg by the LAL method.
- Top Product
- Discover our top product GHR Protein
-
-
- Kommentare
-
A chemically labeled biotinylated protein with ultra sensitivity.
The product is produced using a chemical labeling approach. The primary amines in the side chains of lysine residues and the N-terminus of protein are conjugated with biotins.
Chemical labeling usually results in multiple biotin attachment on a single protein molecule, which could potentially lead to higher detection sensitivity. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Lyophilized
- Buffer
- PBS, pH 7.4
- Handhabung
- Please avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
-
- Target
- Growth Hormone Receptor (GHR)
- Andere Bezeichnung
- Growth Hormone R (GHR Produkte)
- Synonyme
- GHBP Protein, AA986417 Protein, GHR/BP Protein, GHR Protein, ghr Protein, ghr.a Protein, zgc:162141 Protein, growth hormone receptor Protein, growth hormone receptor L homeolog Protein, growth hormone receptor a Protein, GHR Protein, Ghr Protein, ghr.L Protein, ghr Protein, ghra Protein
- Hintergrund
- Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily. GHR contains one fibronectin type-III domain. GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle. The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE. GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
- Molekulargewicht
- 29.6 kDa
- NCBI Accession
- NP_000154
- UniProt
- P10912
- Pathways
- NF-kappaB Signalweg, JAK-STAT Signalweg, Response to Growth Hormone Stimulus
-