IL2 Receptor beta Protein (AA 27-239) (Fc Tag)

Produktnummer ABIN2181388

Produktdetails

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 27-239

Spezies: Human

Quelle: HEK-293 Cells

Aufreinigungstag / Konjugat: Dieses IL2 Receptor beta Protein ist gelabelt mit Fc Tag.

Sequenz: AA 27-239

Produktmerkmale: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 1.0 EU per μg by the LAL method.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: 50 mM Tris, 100 mM Glycine, pH 7.5

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).

Antigendetails

Target: IL2 Receptor beta (IL2RB) (Interleukin 2 Receptor, beta (IL2RB))

Andere Bezeichnung: IL-2 R beta (IL2RB Produkte)

Synonyme: IL2RB Protein, il-2rb Protein, CD122 Protein, IL15RB Protein, P70-75 Protein, IL2RBC Protein, IL-15Rbeta Protein, IL15Rbeta Protein, Il-2/15Rbeta Protein, Il-2Rbeta Protein, p70 Protein, interleukin 2 receptor subunit beta Protein, interleukin-2 receptor subunit beta Protein, interleukin 2 receptor, beta Protein, interleukin 2 receptor, beta chain Protein, IL2RB Protein, LOC510185 Protein, il2rb Protein, Il2rb Protein

Hintergrund: Interleukin-2 receptor subunit beta (IL2RB) is also known as CD122, which Belongs to the type I cytokine receptor family. Type 4 subfamily. IL2RB contains 1 fibronectin type-III domain. IL2RB / CD122 is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2.

Molekulargewicht: 50.7 kDa

NCBI Accession: NP_000869

Pathways: JAK-STAT Signalweg, Growth Factor Binding