LILRB2
(Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 (LILRB2))
Protein-Typ
Recombinant
Proteineigenschaft
AA 22-461
Spezies
Human
Quelle
HEK-293 Cells
Aufreinigungstag / Konjugat
Dieses LILRB2 Protein ist gelabelt mit His tag.
Sequenz
AA 22-461
Produktmerkmale
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 48.6 kDa. The protein migrates as 60-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
LILRB2
Spezies: Human
Wirt: HEK-293 Cells
Recombinant
> 95 % as determined by reducing SDS-PAGE.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Lyophilized
Buffer
PBS, pH 7.4
Handhabung
Please avoid repeated freeze-thaw cycles.
Lagerung
-20 °C
Informationen zur Lagerung
No activity loss was observed after storage at: In lyophilized state for 1 year (4 °C), After reconstitution under sterile conditions for 3 months (-70 °C).
Target
LILRB2
(Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 (LILRB2))
CD85D Protein, ILT-4 Protein, ILT4 Protein, LIR-2 Protein, LIR2 Protein, MIR-10 Protein, MIR10 Protein, leukocyte immunoglobulin-like receptor subfamily A member 3 Protein, leukocyte immunoglobulin like receptor B2 Protein, LOC100433990 Protein, LILRB2 Protein
Hintergrund
Leukocyte immunoglobulin-like receptor subfamily B member 2 (LILRB2) is also known as CD85 antigen-like family member D (CD85d), Immunoglobulin-like transcript 4 (ILT-4), Monocyte / macrophage immunoglobulin-like receptor 10 (MIR-10), which is a member of the the subfamily B class of LIR receptors. LILRB2 is receptor for class I MHC antigens. LILRB2 recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. LILRB2 competes with CD8A for binding to class I MHC antigens. LILRB2 / CD85d inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.