TNF alpha Protein (AA 77-233)

Produktnummer ABIN2181831

Produktdetails

Target: TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

Protein-Typ: Recombinant

Biologische Aktivität: Active

Proteineigenschaft: AA 77-233

Spezies: Human

Quelle: HEK-293 Cells

Marke: ActiveMax®

Sequenz: AA 77-233

Produktmerkmale: This protein carries no "tag". The protein has a calculated MW of 17.4 kDa. The protein migrates as 18 kDa under reducing (R) condition (SDS-PAGE).

Reinheit: >95 % as determined by SDS-PAGE.

Sterilität: 0.22 μm filtered

Endotoxin-Niveau: Less than 0.1 EU per μg by the LAL method.

Güteklasse: HPLC verified

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: PBS, pH 7.4

Handhabung: Please avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C in lyophilized state after receipt. For long term storage, upon reconstitution rhTNFa should be aliquot and store at -20°C or -80°C.

Referenzen

Hua, Oh, Kim, Antonio, Vo, Om, Choi, Kim, Jung, Park, Jeong: "Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients." in: Experimental & molecular medicine, Vol. 52, Issue 4, pp. 629-642, (2020) (PubMed).

Yu, Xu, Qu, Yu, Li, Zhao, Qiu: "Decrease of MiR-31 induced by TNF-α inhibitor activates SATB2/RUNX2 pathway and promotes osteogenic differentiation in ethanol-induced osteonecrosis." in: Journal of cellular physiology, Vol. 234, Issue 4, pp. 4314-4326, (2019) (PubMed).

Zhao, Jiang, Wang, Wu: "Overexpression of microRNA-590-3p promotes the proliferation of and inhibits the apoptosis of myocardial cells through inhibition of the NF-κB signaling pathway by binding to RIPK1." in: Journal of cellular biochemistry, Vol. 120, Issue 3, pp. 3559-3573, (2019) (PubMed).

Antigendetails

Target: TNF alpha (Tumor Necrosis Factor alpha (TNF alpha))

Andere Bezeichnung: TNF-alpha (TNF alpha Produkte)

Synonyme: DIF Protein, TNF-alpha Protein, TNFA Protein, TNFSF2 Protein, RATTNF Protein, Tnfa Protein, tnf Protein, TNF-a Protein, TNFalpha Protein, Tnfsf1a Protein, TNFa Protein, cTNF Protein, Tnf-alpha Protein, tnfa-like Protein, TNF-ALPHA Protein, dif Protein, tnfa Protein, xtnf Protein, tnfsf2 Protein, tnf-alpha Protein, Cachectin Protein, tumor necrosis factor Protein, tumor necrosis factor b (TNF superfamily, member 2) Protein, tumor necrosis factor alpha Protein, tumor necrosis factor a (TNF superfamily, member 2) Protein, TNF Protein, Tnf Protein, tnf Protein, tnfb Protein, tnf-alpha Protein, LOC103694380 Protein, tnfa Protein

Hintergrund: Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

Molekulargewicht: 17.4 kDa

NCBI Accession: NP_000585

Pathways: NF-kappaB Signalweg, Apoptose, Caspase Kaskade in der Apoptose, TLR Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Inflammasome