GREM1 Protein
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- Target Alle GREM1 Proteine anzeigen
- GREM1 (Gremlin 1 (GREM1))
- Protein-Typ
- Recombinant
- Biologische Aktivität
- Active
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Spezies
- Human
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Quelle
- CHO Cells
- Sequenz
- KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
- Produktmerkmale
- Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.07-0.11 μg/mL.
- Reinheit
- < 90 % by SDS-PAGE gel and HPLC analyses.
- Top Product
- Discover our top product GREM1 Protein
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Gremlin 1 (GREM1) (Active) protein
GREM1 Spezies: Ratte Wirt: Escherichia coli (E. coli) WB, SDS Active
Gremlin 1 (GREM1) (AA 25-184) (Active) protein (Fc Tag)GREM1 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Gremlin 1 (GREM1) (AA 25-184) protein (His-IF2DI Tag)GREM1 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Gremlin 1 (GREM1) (AA 25-124) protein (GST tag)GREM1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 1-184) protein (GST tag)GREM1 Spezies: Human Wirt: Wheat germ Recombinant WB, ELISA, AA, AP
Gremlin 1 (GREM1) (AA 25-184) (Active) protein (His tag)GREM1 Spezies: Human Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
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- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Lyophilized
- Handhabung
- As with any protein, exposing Gremlin-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- The recombinant protein is stable for at least 2 years from date of receipt at -20 °C. Reconstituted Gremlin-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20 °C.
- Haltbarkeit
- 24 months
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- Target
- GREM1 (Gremlin 1 (GREM1))
- Andere Bezeichnung
- Gremlin-1 (GREM1 Produkte)
- Hintergrund
- Gremlin-1 (isoform-1) belongs to a group of diffusible proteins which bind to ligands of the TGF-beta family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-beta ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin is highly expressed in the small intestine, fetal brain, and colon and lower expression in brain, prostate, pancreas and skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to and inhibiting the function of BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Gremlin-1 is a 13.7 kDa protein containing 160 amino acid residues.
- Gen-ID
- 26585
- NCBI Accession
- NP_001178251
- OMIM
- 300797307
- UniProt
- O60565
- Pathways
- Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
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